Epiduo Gel Acne Treatment

Around 10% of patients may experience adverse skin reactions with Epiduo 0.3% / 2.5% gel. These reactions are usually mild to moderate and occur early in treatment, gradually improving over time. Common application site reactions include scaling, dryness, erythema (redness), and a burning or stinging sensation. If needed, it's recommended to use a moisturiser, temporarily reduce application frequency, or pause usage temporarily before returning to a once-daily schedule.   

Skin-related adverse events occur more frequently with Epiduo 0.3% / 2.5% gel compared to Epiduo 0.1% / 2.5%. 

Less common side effects (occurs in up to 1 in 100 individuals): 

• redness of the eyelid 

• tingling or sensation of pins and needles at the application site 

• itching of the skin, allergic skin reaction 

• rash 

• dry skin 

Always read the patient information leaflet prior to using any medication. 

Patient information leaflet for Epiduo 0.1%/2.5% gel 

Patient information leaflet for Epiduo 0.3%/2.5% gel

The skin should be clean and dry before application. Apply a thin layer of gel evenly over the entire acne-affected areas of the face and/or the neck, once a day at bedtime. Avoid contact with the eyes, lips, nostrils, and mucous membranes. Wash your hands thoroughly straight after you have applied Epiduo gel.  

If you do not see any improvement after 4-8 weeks you should discuss with your doctor whether to continue Epiduo or try an alternative treatment. 

Do not apply cosmetics (such as other facial creams or make-up) before the daily application of Epiduo gel. These products can be used after the applied gel has dried.

Epiduo is a conveniently applied gel offered in two strengths: adapalene 1 mg (0.1% w/w) with benzoyl peroxide 25 mg (2.5% w/w) and adapalene 3 mg (0.3% w/w) with benzoyl peroxide 25 mg (2.5% w/w). The product is packaged in 45mg tubes. The doctor will decide which strength of Epiduo gel you need, depending on the severity and appearance of your acne.  

Don’t stop using Epiduo gel unless your healthcare provider advises you do - if you stop too soon, your acne could come back. If you’ve forgotten to use your daily dose of Epiduo gel, apply your next dose at the usual time. Don’t use a double dose to make up for any forgotten doses.

If your symptoms return after treatment, talk to your healthcare provider who will review your treatment.

Epiduo is a gel that uses two active ingredients, adapalene and benzoyl peroxide, to treat acne. Adapalene acts on the skin processes that cause acne while benzoyl peroxide is an antimicrobial agent which also softens and peels the outer layer of the skin.

According to the NHS, some patients will start to see results after several weeks, though most will need to apply it for a couple of months before their acne improves.

To use Epiduo gel:

• Clean and dry your skin before use

• Apply a thin film of gel evenly over acne affected areas once a day at bedtime

• Avoid your eyes, lips and nostrils

• Wash your hands after use

For more information about application, read the patient information leaflet.

Epiduo treats active acne and may help post-inflammatory marks over time. Treating acne may help reduce the risk of new scarring, but existing scars may need separate assessment.