Low-Dose Aspirin

What is low-dose aspirin?

Low-dose aspirin (commonly 75mg to 150mg per day) is a form of aspirin taken to prevent blood clots. It is not used for pain relief like standard 300mg aspirin, but rather for its antiplatelet effect to reduce the risk of heart-related conditions. It is known by brand names like Danamep, Mandaprin, and Nu-Seals, and you can get it on prescription or buy it from pharmacies[1]. 

What is low-dose aspirin used for?

Low-dose aspirin is typically prescribed to reduce the risk of serious cardiovascular conditions. It may be recommended for people who[1]: 

• Have had a heart attack or stroke 

• Have angina or peripheral arterial disease 

• Have undergone heart surgery (such as a coronary artery bypass) 

• Are at high risk of pre-eclampsia during pregnancy (prescription only

How does low-dose aspirin work?

Aspirin works by preventing platelets in the blood from clumping together. This reduces the risk of blood clots forming in narrowed arteries, helping maintain blood flow and reducing the risk of heart attack and stroke[1]. 

Who can take low-dose aspirin?

This medication is suitable for most people over 16 years with a high risk of cardiovascular diseases, or pregnant individuals at risk of pre-eclampsia.  You should speak to a doctor first if you[1]: 

• Have a history of stomach ulcers or bleeding disorders 

• Are allergic to aspirin or NSAIDs or have asthma triggered by aspirin 

• Have high blood pressure, indigestion, heavy periods, asthma, lung disease, blood clotting problems, liver issues, kidney problems, or gout 

• Have recently had a stroke 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

What is the typical dosage of low-dose aspirin?

The standard dose of low-dose aspirin is[1]: 

• 75mg once daily for most uses, including to prevent a heart attack or stroke  

• 75mg or 150mg daily during pregnancy if prescribed 

• Possibly up to 300mg daily initially following a heart attack or stroke, then reduced as advised 

How do you take low-dose aspirin?

Low-dose aspirin comes as several different types of tablets[1]: 

• Standard: tablets you swallow whole with water  

• Soluble: tablets that you dissolve in a drink of water  

• Enteric coated or gastro-resistant: tablets that you swallow whole with water. These are designed to be more gentle on your stomach 

Low-dose aspirin should be taken[1]: 

• Once daily, ideally with or after food 

• Whole (not chewed) if using enteric-coated tablets 

• At least two hours apart from indigestion remedies 

Can you stop taking low-dose aspirin?

Do not stop taking low-dose aspirin without consulting your doctor. It is usually prescribed for long-term use to prevent serious health issues[1]. 

What do you do if you take too much low-dose aspirin?

Taking one or two extra tablets is unlikely to cause harm, but more than 12 tablets in 24 hours can lead to serious symptoms like dizziness, nausea, confusion, or ringing in the ears. Seek medical attention immediately if this happens[1]. 

What do you do if you forget to take low-dose aspirin?

If you forget to take your aspirin, take it as soon as you remember. Skip it if it’s nearly time for your next dose and do not double up to make up for a missed dose[1]. 

How do you store low-dose aspirin?

You should store aspirin in a cool, dry place away from heat and moisture. Keep it in its original packaging and out of reach of children[1].  

What medicines can’t you take with low-dose aspirin?

It is generally safe to take with[1]: 

• Paracetamol for pain or fever 

Use with caution or avoid if taking[1]: 

• NSAIDs (e.g. ibuprofen, naproxen) 

• Other blood thinners (e.g. warfarin, clopidogrel) 

• Steroids (e.g. prednisolone) 

• Organ rejection medicine (e.g. ciclosporin, tacrolimus) 

• Methotrexate, lithium, digoxin 

• Diuretics 

• ACE inhibitors 

• High blood pressure medicine (e.g. furosemide, ramipril) 

• Diabetes medicine (e.g. insuling, gliclazide) 

• Herbal supplements such as turmeric 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of low-dose aspirin?

Some side effects are more common than others. You may experience[1]: 

• Indigestion 

• Bruising or bleeding more easily 

Serious but rare side effects may include[1]: 

• Stomach ulcers or bleeding 

• Liver problems (yellowing of skin or eyes) 

• Blood in vomit, urine, or stools 

• Swelling of hands or feet (water retention) 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about low-dose aspirin

When will I feel better? 
You may not feel different, but it helps reduce long-term risks[1]. 

Can I take low-dose aspirin long-term? 
Yes, it is often prescribed for lifelong use[1]. 

Does it cause stomach ulcers? 
It can, especially with long-term or high-dose use. Speak to your doctor about stomach protection[1]. 

Are there alternatives to low-dose aspirin? 
Yes, clopidogrel is sometimes used instead[1]. 

Can everyone take it to prevent heart attacks? 
No, only people at high risk should take it[1]. 

Does low-dose aspirin affect contraception? 
No, it does not affect any contraceptive method[1]. 

Can I drink alcohol with it? 
In moderation, yes – but alcohol can increase the risk of stomach bleeding[1]. 

Can I take low-dose aspirin during pregnancy? 
Only if prescribed, often for pre-eclampsia prevention[1]. 

What if I need surgery? 
Inform your doctor – you may need to stop taking low-dose aspirin temporarily[1]. 

For the official NHS guide to low-dose aspirin, visit their website.