Clopidogrel

What is clopidogrel?

Clopidogrel is an antiplatelet medicine. It helps prevent blood clots by stopping platelets (a type of blood cell) from sticking together. It’s only available on prescription and comes in tablet form[1]. 

What is clopidogrel used to treat?

Clopidogrel is used to reduce the risk of blood clots in people who have or have had[1]: 

• Heart attack 

• Some forms of stroke or transient ischaemic attack (TIA) 

• Acute coronary syndrome 

• Peripheral arterial disease 

• Atrial fibrillation (in some cases) 

• Coronary stent placement or heart surgery 

How does clopidogrel work?

When blood vessels are damaged, platelets clump together to form clots. Clopidogrel acts on platelets, reducing their ability to stick together. This lowers the risk of clots forming, which can lead to heart attacks or strokes[2]. 

Who can take clopidogrel?

Clopidogrel is generally safe for adults aged 18 years and over, but it may not be suitable if you[1]: 

• Have active bleeding (e.g., stomach ulcer) 

• Have an increased risk of bleeding  

• Have liver or kidney problems  

• Due to have surgery 

• Are pregnant, trying to get pregnant or breastfeeding 

• Are allergic to clopidogrel, thienopyridines (like prasugrel) or any of the ingredients listed as part of the medicine 

Please tell your doctor or pharmacist about any conditions you may have before you start treatment and always follow the directions provided. Please read your patient information leaflet for more information before you take clopidogrel[3]. 

How do you take clopidogrel?

Take clopidogrel at the same time every day. Swallow the tablets whole with a drink of water. They can be taken with or without food[1].  

What is the typical dosage of clopidogrel?

The usual dose is 75 mg once daily. Occasionally higher doses are prescribed. 

How long you take clopidogrel for depends on your condition. It could be a few weeks or months or for life[1]. 

Can you stop taking clopidogrel?

You should not stop taking clopidogrel unless told to by your doctor or pharmacist. Stopping early can increase your risk of a heart attack or stroke[1]. 

What do you do if you take too much clopidogrel?

Taking 1 or 2 extra tablets of clopidogrel may prolong bleeding time and subsequent bleeding complications. Call 111 for advice if you think you’re at risk of harm[1]. 

What do you do if you forget a dose of clopidogrel?

If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Never take 2 doses at the same time[1]. 

What are the side effects of clopidogrel?

The most common side effects of clopidogrel are[1]: 

• Easy bruising 

• Nosebleeds 

• Diarrhoea or indigestion 

• Headache or dizziness 

The most serious side effects can include[1]: 

• Uncontrolled bleeding 

• Blood in your wee or stool 

• Signs of liver problems 

If you experience any serious side effects, you should contact your doctor or call 111 immediately. 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2].

Medicines you can and can’t take with clopidogrel

Avoid or use caution with[1]: 

• NSAIDs (e.g., ibuprofen, naproxen) – increased bleeding risk 

• Warfarin or other blood thinners – may require monitoring as increased risk of bleeding  

• Omeprazole – may reduce clopidogrel’s effectiveness 

• Antidepressants - such as SSRI’s (citalopram, sertraline, fluoxetine) – increased risk of bleeding 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the directions provided. Please read the Patient Information Leaflet for further information before you take clopidogrel[2]. 

Frequently asked questions about clopidogrel

Can I drink alcohol with clopidogrel? 
Yes, but in moderation. Excess alcohol can irritate your stomach[1].  

Can I take clopidogrel long-term? 
Yes, if prescribed. Some people take it for months or years depending on their condition[1]. 

Is it safe during pregnancy? 
Usually not often recommended in pregnancy unless clearly needed. Please discuss with your doctor or pharmacist[1]. 

Can I take painkillers with clopidogrel? 
Paracetamol is safe to take with clopidogrel. Avoid NSAIDs like Ibuprofen unless advised by your doctor[1].

For the official NHS guide to clopidogrel, visit their website.