Lisinopril

What is lisinopril?

Lisinopril is a prescription-only medicine within a group of drugs known as ACE inhibitors (angiotensin-converting enzyme inhibitors). It is commonly used to treat various heart and blood vessel conditions[1]. 

What is lisinopril used for?

Lisinopril is used to treat a range of different conditions. These can include high blood pressure (hypertension), heart failure, or in recovery after a heart attack, to help improve outcomes. It’s also used for kidney problems in people with diabetes[1]. 

How does lisinopril work?

Lisinopril works by blocking the enzyme that converts angiotensin I to angiotensin II  which causes blood vessels to narrow. By reducing the production of this substance, lisinopril allows the blood vessels to relax and widen, helping to lower blood pressure which reduces overall strain on the heart[1]. 

Who can take lisinopril?

Most adults and some children under specialist supervision can take lisinopril. However, it is not suitable for people who are pregnant or breastfeeding, who have previously experienced angioedema, or have had an allergic reaction to lisinopril, another ACE inhibitor or any of the ingredients listed as part of your medicine[1]. 

Lisinopril is also not suitable for those taking certain medicines that may interact with lisinopril. Please discuss your full medical history and current medication, including any vitamins and supplements, with your doctor to make sure lisinopril is safe for you to take[1]. 

Please tell your doctor or pharmacist about any conditions you may have before you start treatment and always follow the instructions in the Patient Information Leaflet[2]. 

How do you take lisinopril?

Lisinopril is usually taken once daily, at the same time each day. It can be taken with or without food by swallowing the tablet whole with a drink of water.

What is the typical dosage of lisinopril?

Lisinopril is available in 2.5mg, 5mg, 10mg and 20mg tablets as well as an oral solution. The typical starting dose for adults is 10mg once daily for high blood pressure – although this may be adjusted depending on how you respond to treatment and your medical history. For children, the dose is based on age, body weight and medical condition, and is determined by a specialist on a case-by-case basis[1]. 

Can you stop taking lisinopril suddenly?

You should not stop taking lisinopril without first getting medical advice. Stopping suddenly can cause your blood pressure to rise again or worsen symptoms of heart failure, so it’s essential to get the proper guidance first. Your doctor may gradually reduce your dose if stopping is necessary[1]. 

What should you do if you take too much lisinopril?

Taking too much lisinopril can cause low blood pressure, dizziness, fainting or a slow heart rate. If you experience these, you should get immediate medical attention. If you are in the UK, call 111 or go to your nearest A&E department – take the medicine packaging with you if possible[1]. 

What should you do if you forget a dose of lisinopril?

You can take a missed dose of lisinopril if you remember soon after it was due. But if you forget to take a dose of lisinopril and it’s almost time for your next dose, simply skip the one you missed and carry on as normal. You shouldn’t take a double dose to make up for missing one[1]. 

What medicines should you avoid while taking lisinopril?

Lisinopril can interact with certain other medicines, including[1]: 

• Aliskiren increases risk of renal inpatient and should not be used in renal impairment or diabetic patients 

• Allopurinol is predicted to increase risk of allergic and blood reactions  

• Azathioprine is predicted to increase the risk of low red and white blood cells  

• Everolimus potentially increases the risk of angioedema 

• Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, which may affect kidney function 

• Potassium supplements or potassium-sparing diuretics, which can increase potassium levels in the blood 

• Lithium, as lisinopril can increase the risk of lithium toxicity 

Please note this is not a complete list of interactions, always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of lisinopril?

The most common side effects of lisinopril are usually mild and pass quickly – these include a dry, persistent cough, dizziness or light-headedness, a headache, tiredness, or nausea[1]. 

In some rare but more serious cases, less common lisinopril side effects include[1]: 

• Swelling of the face, lips or throat, which could be a sign of angioedema 

• Kidney problems 

• High levels of potassium in the blood 

You should contact your GP or call NHS 111 if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about lisinopril

How long does lisinopril take to work? 

Blood pressure may begin to lower within a few hours after you take lisinopril, but the full effect can take several weeks[1]. 

Can I drink alcohol while taking lisinopril? 

It’s usually safe to drink moderate amounts of alcohol when you take lisinopril. Alcohol can increase the risk of dizziness or fainting, especially when starting treatment, so it’s best to avoid drinking excessive amounts[1]. 

Does lisinopril cause a cough? 

Yes, a dry and persistent cough is a known side effect of lisinopril. Speak to your doctor if it becomes bothersome or worrying[1]. 

Is lisinopril safe in pregnancy? 

No, lisinopril can harm an unborn baby and it should not be taken during pregnancy[1]. 

Can I take painkillers with lisinopril? 

You should avoid NSAIDs – like ibuprofen – while taking lisinopril, unless advised by your doctor, as they may affect your kidneys. Other painkillers, such as paracetamol, are generally safe. Consult your doctor or pharmacist for further information[1]. 

What should I do if I feel dizzy after taking lisinopril? 

If you feel dizzy when taking lisinopril, try to sit or lie down until the dizziness passes. This is a common side effect when starting treatment or increasing the dose, and it should pass relatively quickly. Contact your doctor if it becomes concerning[1]. 

Can I take lisinopril long term? 

Yes, lisinopril is often used as a long-term treatment for a range of conditions. Your doctor will monitor you regularly and may adjust your dose if needed[1]. 

Will I need regular blood tests while taking lisinopril? 

Yes, while taking lisinopril your doctor should regularly check your kidney function and potassium levels to ensure your wellbeing[1]. 

Can I take lisinopril with food? 

Yes, food does not affect how lisinopril works, so you can usually take it with or without food. Your doctor will advise you of what’s best according to your personal circumstances[1]. 

For the official NHS guide to lisinopril, visit their website.