Fluticasone Skin Cream

What is fluticasone skin cream?

Fluticasone skin cream is a prescription-only, potent topical corticosteroid used to treat inflammatory skin conditions. It helps reduce redness, swelling, and itching by acting on the immune response in the skin. Brand names include Cutivate[1]. 

You can also find advice here on fluticasone inhalers and fluticasone nasal spray and drops. 

What is fluticasone skin cream used for?

Fluticasone cream is used to treat a range of non-infected inflammatory skin conditions. These include[1]: 

  • Eczema 

  • Psoriasis 

  • Dermatitis 

  • Insect bites 

  • Prickly heat 

  • Other steroid-responsive skin conditions 

It should not be used for acne, rosacea, perioral dermatitis, or infected skin unless directed by your pharmacist, doctor or used in a product that contains an added anti-infective agent[1]. 

How does fluticasone skin cream work?

Fluticasone works by reducing inflammation in the skin. Specifically, it[1]: 

  • Suppresses the immune response in the affected area 

  • Reduces redness, swelling, and itching 

  • As a potent steroid, fluticasone is stronger than mild or moderate corticosteroids. 

Who can take fluticasone skin cream?

Fluticasone is suitable for most adults and children over 1 year old, but there are important exceptions. Speak to your doctor first if you[1]: 

  • An allergy to fluticasone 

  • Have broken skin, cuts, or itchy skin 

  • Have a skin infection 

  • Have acne or rosacea 

  • Have perioral dermatitis 

  • Have anal or genital itching 

  • Are pregnant, trying to get pregnant, or breastfeeding 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

What is the typical dosage of fluticasone skin cream?

Your doctor or pharmacist will explain how much to use and for how long. Usually, it’s[1]: 

  • Apply once or twice daily for up to 4 weeks 

  • Use the fingertip unit (FTU) method for measurement: 

  • 1 FTU is the amount of cream squeezed from the tip of an adult finger to the first crease is enough to treat an area twice the size of the palm of your hand 

  • Reduce frequency once symptoms improve 

How do you take fluticasone skin cream?

Follow these steps to apply fluticasone cream effectively[1]: 

  • Wash hands before and after use 

  • Apply a thin layer to the affected skin 

  • Rub in gently until absorbed 

  • Avoid using dressings unless advised by a doctor 

  • Do not apply near the eyes or on the eyelids 

Can you stop taking fluticasone skin cream?

This depends on how long you’ve been using it[1]: 

  • If used short-term, you can usually stop without issue 

  • If used for a prolonged period, sudden withdrawal may trigger a steroid withdrawal reaction (such as redness or burning). Your doctor or pharmacist may recommend tapering use gradually 

What do you do if you take too much fluticasone skin cream?

Using too much over a long time may lead to side effects. If this happens, wipe off excess cream. Contact your doctor or pharmacist if you experience skin thinning, stretch marks or hormonal symptoms[1]. 

What do you do if you forget to take fluticasone skin cream?

If you miss a dose[1]: 

  • Apply as soon as you remember 

  • If your next dose is soon, skip the missed one 

  • Do not apply a double amount 

How do I store fluticasone skin cream?

Store the cream safely to maintain its effectiveness[1]: 

  • Keep below 30°C 

  • Use within 6 months of opening 

  • Store in original packaging 

  • Keep out of reach of children 

  • Do not use after the expiry date 

What medicines can’t you take with fluticasone skin cream?

Fluticasone skin cream is generally safe with most other medicines, but you should tell your doctor or pharmacist if you’re using[1]: 

  • Other topical corticosteroids 

  • Immunosuppressants like HIV medication 

  • Antifungal medication 

  • Any medicine that affects wound healing 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of fluticasone skin cream?

As with all steroids, side effects are possible. These include: 

Common side effects are often mild and stop after you’ve used it for a few days. These include: 

  • Itching 

  • Burning or stinging 

Rare or serious side effects occur in less than 1 in 10,000 people, but are more likely if you use fluticasone for an extended period of time[1]: 

  • Skin thinning 

  • Stretch marks 

  • Excess hair growth 

  • Skin discolouration 

  • Adrenal gland problems 

  • Pus-filled bumps under the skin 

  • Blurred vision or eyesight changes 

  • Steroid withdrawal symptoms (such as redness, peeling, or stinging after stopping) 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1] 

  • Difficulty breathing  

  • Tightness in throat and chest  

  • Swelling of the tongue or throat  

  • Feeling faint or dizzy  

  • Blue/grey skin or lips  

  • Loss of consciousness 

 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about fluticasone skin cream

Can I use fluticasone skin cream on my face? 
Only if prescribed, as facial skin is more sensitive[1]. 

Can children use fluticasone skin cream? 
Yes, but only with specialist advice[1]. 

Can I use it long-term? 
No – long-term use increases the risk of side effects[1]. 

Can I use fluticasone skin cream with moisturisers? 
Yes – apply steroid first, wait about 30 minutes, then apply the moisturiser. If you apply the moisturiser first, you may have to wait longer[1]. 

Can I use it during pregnancy? 
Only if advised by your doctor[1]. 

Can I use fluticasone skin cream while breastfeeding? 
Yes but avoid applying it near the breast area[1]. 

Can I use fluticasone skin cream with other skin treatments? 
Yes but check with your doctor or pharmacist first[1]. 

For the official NHS guide to fluticasone skin creams, visit their website. 


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The information provided on this Medicines A-Z page is intended for general informational purposes only and was accurate as of June 2025. It is designed to offer simple, patient-friendly summaries of prescribed medications based on publicly available resources, including those from the National Health Service (NHS). This content does not constitute medical advice, diagnosis, or treatment and is not a substitute for professional guidance from a qualified healthcare professional, such as a doctor or pharmacist.

Patients should always consult their healthcare professional before starting, stopping, or changing any prescribed medication, and must inform them of any known allergies, medical conditions, or other medications being taken to ensure safe use. The inclusion of a medication on this page does not guarantee its availability, suitability, or approval for use in all cases, as prescribing decisions are made by healthcare professionals based on individual patient needs.

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