Clobetasone

What is clobetasone?

Clobetasone is a moderately potent corticosteroid used to treat inflammatory skin conditions. It works by reducing redness, swelling, and itching. It is available as a cream or ointment and is sold under brand names such as Eumovate and Clobavate. It is available on prescription and you are also able to buy certain products over the counter.. There is also a similar cream called clobetasol, however this is much stronger and available on prescription only[1].

What is clobetasone used for?

Clobetasone is commonly prescribed for various non-infectious skin conditions, including[1]: 

• Eczema 

• Dermatitis 

• Insect bites 

• Allergic skin reactions 

• Seborrhoeic dermatitis 

• Nappy rash (under medical supervision) 

It is not suitable for treating acne, rosacea, or untreated skin infections. 

How does clobetasone work?

Clobetasone works by suppressing the production of chemicals that cause inflammation in the skin. This helps to reduce swelling and redness, relieve itching and soothe irritated skin[1]. 

Who can take clobetasone?

Clobetasone is suitable for most adults and some children over 12. Children under 12 should only use it on prescription under medical supervision[1]. 

Speak to your doctor first if you[1]: 

• Have skin infections (bacterial, viral, or fungal) 

• Have rosacea or acne 

• Are allergic to clobetasone or any of the cream’s ingredients 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].

What is the typical dosage of clobetasone?

Clobetasone comes in a strength of 0.05%, and contains 5mg of clobetasone butyrate in each 10g of cream and ointment. Clobetasone should be used sparingly[1]: 

• Typically applied once or twice daily for up to a week 

• Use a thin layer, gently rubbed into the affected area 

• Measure using ‘fingertip units’ (FTUs) for accuracy  

Always use the lowest effective dose for the shortest possible time. 

How do you take clobetasone?

To apply clobetasone properly[1]: 

• Wash and dry hands before and after use 

• Apply a thin layer to clean, dry skin 

• Do not cover with bandages unless advised by a doctor 

• Avoid applying to broken or infected skin unless prescribed 

• Leave a gap of 8 to 12 hours between applications 

Can you stop taking clobetasone?

Yes, but it should be done carefully if you've used it for a long time. Gradually reduce usage to prevent rebound symptoms and follow your doctor’s or pharmacist’s guidance when stopping[1]. 

What do you do if you take too much clobetasone?

Using too much clobetasone over time can lead to[1]: 

• Skin thinning 

• Stretch marks or fragile skin 

• Hormonal imbalances (especially if used on large areas or under dressings) 

If accidentally swallowed or used excessively, contact a healthcare professional immediately. 

What do you do if you forget to take clobetasone?

If you forget a dose, apply it as soon as you remember. If it’s nearly time for your next dose, skip the missed one. Do not double the dose[1]. 

How do you store clobetasone?

Proper storage helps maintain effectiveness[1]: 

• Store at room temperature 

• Keep away from direct sunlight and heat 

• Do not use past the expiry date 

• Keep out of sight and reach of children  

What medicines can’t you take with clobetasone?

Clobetasone is generally safe with most medicines, but[1]: 

• Avoid combining with other topical steroids unless advised 

• Tell your doctor or pharmacist if you use other skin treatments 

• Speak to your doctor first if you’re taking medicine for HIV or fungal infections 

• Let them know if you're pregnant, breastfeeding, or planning to be  

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of clobetasone?

Common side effects include[1]: 

• Burning or stinging when first applied 

• Dry or itchy skin 

Less common side effects may include[1]: 

• Skin thinning 

• Stretch marks 

• Swollen or reddening skin 

• Discolouration 

• High blood sugar 

• Eyesight problems 

• Increased hair growth 

Rare but serious effects include[1]: 

• Worsening of untreated skin infections 

• Adrenal suppression 

• Hormonal effects such as fatigue or weight gain (from overuse) 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2].

Frequently asked questions about clobetasone

How long can I use clobetasone? 
Usually for up to 7 days, unless your doctor advises otherwise[1]. 

Can I use it during pregnancy? 
Only under medical advice – use the lowest effective dose[1]. 

Can I use moisturisers with clobetasone? 
Yes. Apply moisturiser after clobetasone, leaving a 30-minute gap[1]. 

Can children use clobetasone? 
Yes, but only under a doctor’s supervision and for short durations[1]. 

Can I use it on broken skin? 
Not unless specifically prescribed[1]. 

Does clobetasone treat fungal infections? 
No – it can actually worsen fungal infections[1]. 

For the official NHS guide to clobetasone, visit their website.