Clobetasol

What is clobetasol?

Clobetasol is a very strong corticosteroid used to treat severe skin conditions. It works by reducing inflammation, redness, and itching by suppressing the immune response in the skin. It is available in different forms including creams, ointments, scalp treatments, and shampoos, and is sold under brand names such as Dermovate, ClobaDerm, and Etrivex. It is only available on prescription[1].  

What is clobetasol used for?

Clobetasol is prescribed to manage severe inflammatory skin conditions, including[1]: 

• Eczema 

• Psoriasis (including plaque and scalp psoriasis) 

• Lichen planus 

• Lichen sclerosus 

• Atopic dermatitis 

• Contact dermatitis 

• Seborrhoeic dermatitis 

• Nummular eczema  

How does clobetasol work?

Clobetasol works by blocking the release of chemicals that cause inflammation in the skin. This helps to[1]: 

• Reduce swelling and redness 

• Calm itching 

• Restore the skin’s normal appearance and feel  

Who can take clobetasol?

Depending on the formulation, Clobetasol is suitable for most adults and some children. Adults and children over 1 can use the cream, ointment, or scalp treatment. Shampoo is not recommended for children under 2. You should speak to your doctor first if you[1]: 

• Have skin infections or broken skin or cuts 

• Have acne or rosacea 

• Have skin problems on your face 

• Are allergic to clobetasol or ingredients such as cetostearyl alcohol or chlorocresol  

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

What is the typical dosage of clobetasol?

Clobetasol is available in different formulations and strengths. Dosage typically includes[1]: 

• Cream, ointment, or scalp treatment: 0.5mg per 1g 

• Shampoo: 500mg per 1g 

 The frequency and duration of time it is used is decided on by the prescriber, depending on factors such as severity of symptoms. 

Children under 12 should not use it for longer than 5 days unless advised by a doctor.  

How do you use clobetasol?

You usually take clobetasol once or twice daily for up to a week. To apply clobetasol safely and effectively[1]: 

• Apply a thin layer to the affected area once or twice daily 

• Use the ‘fingertip unit’ to guide quantity – one fingertip covers an area twice the size of your palm 

• Wash hands before and after use 

• Wait 30 minutes before applying other products like moisturisers 

• For shampoo: apply to a dry scalp, leave for 15 minutes, then rinse thoroughly [6]  

Can you stop taking clobetasol?

You should not stop clobetasol suddenly if you've used it for a long time. Your doctor or pharmacist may advise tapering your dose gradually to avoid flare-ups or withdrawal reactions. Prolonged use can cause side effects like skin thinning or adrenal suppression[1]. 

What do you do if you take too much clobetasol?

Using too much clobetasol over time can lead to side effects, including[1]: 

• Skin thinning or stretch marks 

• Hormonal imbalances 

• Adrenal gland suppression  

If you experience symptoms like unusual fatigue, dizziness, or nausea, contact your doctor or call NHS 111. 

What do you do if you forget to take clobetasol?

If you miss a dose[1]: 

• Apply it as soon as you remember 

• If it’s almost time for the next dose, skip the missed one 

• Never apply a double amount to make up for a missed dose

How do I store clobetasol?

To keep your medication safe and effective[1]: 

• Store below 25°C 

• Keep away from heat, moisture, and direct sunlight 

• Do not freeze 

• Keep out of sight and reach of children  

What medicines can’t you take with clobetasol?

Avoid combining clobetasol with other steroid treatments unless instructed. Speak to your doctor or pharmacist if you are using: 

• Other topical treatments 

• Oral or inhaled steroids 

• Antifungal or HIV medications (these can increase the risk of side effects) 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of clobetasol?

Like all medicines, clobetasol can cause side effects. Common ones include burning or stinging, dry or irritated skin in the moments after you apply the medicine. You should ask your doctor if you need to carry a steroid emergency card with you[1]. 

More serious side effects, for which you should seek urgent help, include[1]: 

• Skin thinning 

• Skin infection 

• Raised bumps filled with pus under the skin if you have psoriasis 

• Stretch marks 

• High blood sugar 

• Eyesight changes 

• Adrenal suppression 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about clobetasol

How quickly does clobetasol work? 
You may notice improvement within a few days. 

Can I use clobetasol on my face? 
Only if prescribed, and for no more than 5 days[1]. 

Can I use moisturiser with clobetasol? 
Yes – but wait at least 30 minutes after applying clobetasol to use your moisturiser[1]. 

Can I use clobetasol long-term? 
Only under the advice of your doctor or pharmacist. Long-term use raises the risk of side effects[1]. 

What if my condition worsens? 
Stop using it and consult your doctor or pharmacist immediately[1]. 

Can I use it during pregnancy or breastfeeding? 
Only if your doctor or pharmacist recommends it[1]. 

Can I drink alcohol while using it? 
Yes – alcohol does not interact with clobetasol[1]. 

What if I get it in my eyes or mouth? 
Rinse thoroughly with water and seek medical advice if irritation continues[1]. 

For the official NHS guide to clobetasol, visit their website.