Everything you need to know about switching weight loss medications

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Written by: Dr Kieran Seyan

Everything you need to know about switching weight loss medications

There are several reasons why you might want or need to switch from one weight loss medication to another, including price, side effects, or simply a desire to try a different option. It makes sense that you’d also have questions about the process, how it will impact your weight loss journey, and what to expect as you transition. This guide is designed to answer all your questions, so you can feel safe and happy making the change with full consultation and support from your doctor. 

What are your options?

If you’re on a weight loss treatment, it’s sensible to review your current treatment plan regularly with your doctor. You may be happy to continue with your current plan, explore alternatives, or simply get some advice from our experts. 

Continue your current treatment

Continue your current treatment

Our clinical team can review your treatment plan during a consultation to ensure it remains suitable for your health needs, and they might suggest that it’s best for you to stay on the weight loss treatment you’re already on.
Explore weight loss treatment options

Explore weight loss treatment options

If you are considering switching to or from Mounjaro (tirzepatide) and Wegovy (semaglutide), our clinicians can provide guidance on suitable options tailored to your medical history and needs. A consultation is always required to determine if a change in treatment is appropriate for you.
Discuss your options with a clinician

Discuss your options with a clinician

If you just have questions about your current weight loss treatment or need guidance on what your next steps could be, our registered clinicians are available for a confidential consultation to provide personalised advice based on your health needs.

New patients get £30 off their first consultation with code A9K4TZ. Offer expires 31st May 2026.

Weight loss treatments: a side-by-side view

Take a look at our up-to-date dose and price tables for both Wegovy and Mounjaro.  

Wegovy & Mounjaro: An example treatment plan

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Wegovy 0.25mg-7.2mg

Active ingredient: Semaglutide

Tick Circle
Avg. weight loss * up to 20.7% ✝
Tick Circle
Weekly injection
Tick Circle
Also prevents against heart disease
Tick Circle
Suitable for use alongside oral contraception
Dose strength 1 0.25mg
£94.99
Dose strength 2 0.5mg
£114.99
Dose strength 3 1mg
£144.99
Dose strength 4 1.75mg
£169.99
Dose strength 5 2.4mg
£189.99
Dose strength 67.2mg
£269.99
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Mounjaro 2.5mg-15mg

Active ingredient: Tirzepatide

Tick Circle
Avg. weight loss ** up to 22.5% ✝
Tick Circle
Weekly injection
Tick Circle
Has also been used to treat some people with type 2 diabetes
Tick Circle
Not suitable for use alongside oral contraception
Dose strength 1 2.5mg
£169.99
Dose strength 2 5mg
£189.99
Dose strength 3 7.5mg
£244.99
Dose strength 4 10mg
£279.99
Dose strength 5 12.5mg
£289.99
Dose strength 6 15mg
£299.99

* Clinical studies show Wegovy (semaglutide), when combined with a calorie-controlled diet and exercise, resulted in an average weight loss of approximately 15% over 68 weeks at the highest dose. Individual results vary, and side effects may occur. Consult a clinician for full details

** Clinical studies show Mounjaro (tirzepatide), when combined with a calorie-controlled diet and exercise, resulted in an average weight loss of approximately 20.9% over 36 weeks and 25.3% over 88 weeks at the highest dose. Individual results vary, and side effects may occur. Consult a clinician for full details.  

Data sourced from clinical trials (e.g. STEP UP trial 3b for Wegovy 7.2mg, SURMOUNT for Mounjaro). Weight loss varies by individual, and treatments carry risks, including gastrointestinal side effects. A clinician will assess suitability. 

Your current Mounjaro dose

Thinking about switching from Mounjaro to Wegovy? Click on your current Mounjaro dose to see what might be suitable for you. 

For patients transitioning from Mounjaro to Wegovy, the starting dose may not always be the lowest, depending on clinical evaluation. The table below provides the suggested Wegovy dose based on the current Mounjaro dose, subject to clinical assessment. 

Your clinician will determine the most appropriate Wegovy dose based on a review of your medical history, including any side effects experienced while using Mounjaro. This evaluation may result in adjustments to the starting dose to better meet your individual needs. 

Your current Wegovy dose

Thinking about switching from Wegovy to Mounjaro? Click on your current Wegovy dose to see what might be suitable for you. 

For patients transitioning from Wegovy to Mounjaro, the starting dose may not always be the lowest, depending on clinical evaluation. The table below provides the suggested Mounjaro dose based on the current Wegovy dose, subject to clinical assessment.

Your clinician will determine the most appropriate Mounjaro dose based on a review of your medical history, including any side effects experienced while using Wegovy. This evaluation may result in adjustments to the starting dose to better meet your individual needs. 

If you’re thinking about switching from Mounjaro or Wegovy to the other, take a look at our in-depth guide to both weight loss treatments

Proven weight loss results in clinical studies

Weight Loss Graph

Clinical trials have shown impressive results for GLP-1 weight loss treatments. Wegovy has been shown to help adults with a BMI of 30+ to lose 15% of their body weight on average over 16 months. Mounjaro has been shown to help adults with a BMI of 30+ to lose between 21% and 22.5% of their body weight on average over 17 months. 

How do you safely transition from one weight loss treatment to another?

Whether you’ve decided that you’d like to switch from Mounjaro to Wegovy, or from Wegovy to Mounjaro, you’ll want to know what happens next. You should schedule a consultation to speak with one of our doctors, who will guide you through the process, review your medical history, and ensure that changing your weight loss medication is the right decision for you. If they agree that it is, they will put together a transition plan for you.

How do you stop taking Wegovy?

If switching to Mounjaro, it’s important that you wait at least one week after your last Wegovy injection, and that you do not take more than one medicine at a time. 

How do you start taking Mounjaro?

If you’ve had approval from your Online Doctor consultation to switch your weight loss treatment to Mounjaro, your new treatment plan will begin after at least one week free from Wegovy. You’ll then choose your preferred injection day (the same day each week) and follow the dosing schedule agreed upon with your clinician

How do you stop taking Mounjaro?

If switching to Wegovy, it’s important that you wait at least one week after your last Mounjaro injection, and that you do not take more than one medicine at a time. 

How do you start taking Wegovy?

If you’ve had approval from your Online Doctor consultation to switch your weight loss treatment to Wegovy, your new treatment plan will begin after at least one week free from Mounjaro. You’ll then choose your preferred injection day (the same day each week) and follow the dosing schedule agreed upon with your clinician

Will you experience withdrawal symptoms between treatments?

There are no withdrawal symptoms typically associated with stopping weight loss medications like Wegovy and Mounjaro as you wait a week before starting your new treatment, this is the normal transition period for Mounjaro, so you shouldn’t experience anything unusual. It’s important to maintain any healthy lifestyle changes you’ve made — such as eating a low-calorie diet and regular exercise — to help maintain your weight loss. 

Frequently asked questions about switching weight loss treatments

Yes, it is generally safe to switch between Mounjaro and Wegovy but it needs to be done under medical supervision. Each medication has its own eligibility criteria, works slightly differently and have their own dosing schedule. Your clinician will advise which is the most suitable option for your individual needs, to ensure a safe transition. 

Both Mounjaro and Wegovy can cause similar digestive side effects, like nausea, vomiting and diarrhoea, especially when starting treatment and during dosage increases. When comparing Mounjaro to Wegovy, people often find they can tolerate one better than the other.  

If you had side effects with Mounjaro, that doesn't mean you'll experience side effects with Wegovy, as they are different medications and everyone responds differently. 

No two people will experience the same transition period. Initially, you may notice mild side effects, such as nausea, constipation, or bloating, you might feel fuller quicker, or you might not experience anything at all. Appetite changes may also occur, and some side effects can persist for the first few weeks, but everything usually settles down after three weeks, if not sooner. 

Most people who switch from one weight loss treatment to another do not gain weight during the transition period. It's possible to notice small fluctuations, but by maintaining a well-balanced diet, keeping activity levels up, and ensuring adequate hydration, you can keep your progress on track during this short adjustment phase.

You should take it for as long as your doctor recommends. Each person is different, and everyone’s experience of weight loss medication will be unique to them. 

Not always. When switching from Mounjaro to Wegovy, or vice-versa, your clinician will determine the appropriate starting dose based on your medical history, how you previously responded to Mounjaro or Wegovy, and any side effects that you experienced. This approach helps maintain your progress while reducing any potential future side effects. 

If you experience prolonged or severe side effects during the transition, consult your clinician for support and guidance during this phase of your weight loss journey. 

No, you don't need a new diet when switching from Mounjaro to Wegovy, or vice-versa. These medications give better results when combined with a balanced diet and an exercise plan. 

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Advice and information to support weight loss