Tolterodine

What is carbimazole?

Carbimazole is a prescription-only medicine used to manage an overactive thyroid gland, a condition referred to as hyperthyroidism. This condition occurs when the thyroid secretes excessive thyroid hormone, which may result in symptoms such as weight loss, rapid heartbeat, sweating, and anxiety[1]. 

What is tolterodine?

Tolterodine is a prescription-only medicine used to treat symptoms of an overactive bladder (OAB). It belongs to a group of medicines called antimuscarinics, which help reduce spasms in the bladder muscles and improve urinary control. It is sometimes better known by brand names like Netidol, Detrusitol, and Mariosea[1]. 

What is tolterodine used for?

Tolterodine is used to treat urinary symptoms that are often caused by an overactive bladder. These include[1]: 

• Urge incontinence – a sudden, intense need to urinate followed by involuntary leakage 

• Frequent urination – needing to pass urine more often than usual 

• Urgency – a strong, immediate urge to urinate even when the bladder is not full 

• Bedwetting in childre

How does tolterodine work?

Tolterodine works by blocking muscarinic receptors in the bladder wall. These receptors help control the bladder's muscle contractions. By blocking them, tolterodine[1]: 

• Reduces involuntary bladder spasms 

• Increases the bladder's capacity to hold urine 

• Decreases the feeling of urgency and frequency of urination 

Who can take tolterodine?

Tolterodine is suitable for most adults with overactive bladder symptoms. It can also be prescribed to children aged 2 and over under supervision. However, some people should avoid it or use it with caution. You should speak to your doctor first if you[1]: 

• Are allergic to tolterodine or any of its ingredients 

• Have urinary retention (inability to empty the bladder) 

• Have uncontrolled narrow-angle glaucoma 

• Have myasthenia gravis 

• Have severe ulcerative colitis or toxic megacolon 

• Have kidney or liver problems 

• Have heart conditions or abnormal heart rhythms 

• Have digestive or bowel disorders 

• Have a hiatus hernia 

• Have an enlarged prostate 

• Have a condition called autonomic neuropathy 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

How do you take tolterodine?

Tolterodine should be taken exactly as prescribed. Swallow the tablets or capsules whole with a glass of water. Do not crush or chew modified-release capsules. Take it at the same time each day and with or without food[1]. . 

What is the typical dosage of tolterodine?

The dose of tolterodine will depend on the form prescribed and your response to treatment. It is commonly prescribed as[1]: 

• Immediate-release tablets: usually 1mg or 2mg twice a day 

• Modified-release capsules: usually 4mg once daily 

Your doctor or pharmacist may adjust the dose depending on how well the medicine is working and whether you experience side effects. 

Can you stop taking tolterodine?

Do not stop taking tolterodine without checking with your pharmacist or doctor. If you stop suddenly, your bladder symptoms may return. If you want to stop treatment, your health professional will guide you on how to do so safely[1]. 

What do you do if you take too much tolterodine?

An overdose of tolterodine can cause a range of symptoms, including[1]: 

• Rapid heartbeat 

• Excitability or agitation 

• Dilated pupils 

• Difficulty breathing 

Call NHS 111 or go to A&E immediately if you think you’ve taken too much. 

What do you do if you forget to take tolterodine?

If you forget a dose, take it as soon as you remember. If it’s nearly time for your next dose, skip the missed one. Do not take two doses at the same time[1]. 

What medicines can’t you take with tolterodine?

Tolterodine may interact with other medicines. Tell your doctor or pharmacist if you are taking[1]: 

• Antifungal medicines like ketoconazole and itraconazole 

• Macrolide antibiotics like erythromycin and clarithromycin 

• HIV medicines 

• Medicines for heart rhythm problems such as amiodarone or quinidine 

• Other antimuscarinics (e.g. oxybutynin) – may increase side effects 

• Metoclopramide or cisapride – may affect how your gut moves 

• Medicines that work similarly to tolterodine, like fesoterodine 

• Any IBS, asthma, incontinence, motion sickness, or movement disorder medication 

• Mental health and depression medication like haloperidol, benperidol, amitriptyline, imipramine, dosulepin, and clozapine 

• Sedatives 

• Dementia medication like donepezil, tacrine, or rivastigmine 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of tolterodine?

Like all medicines, tolterodine can cause side effects, although not everyone gets them. 

Common side effects include[1]: 

• Dry mouth or eyes 

• Headache 

• Constipation, diarrhoea, vomiting, or nausea 

• Stomach pain 

• Blurred vision 

• Pain when peeing 

• Dizziness or drowsiness (vertigo) 

• Tiredness 

Rare but serious side effects include[1]: 

• Irregular or fast heartbeat 

• Confusion or hallucinations 

• Severe stomach pain, or difficulty pooing and peeing 

• Symptoms suggestive of a urinary tract infection (e.g., burning or pain when urinating) 

• Swollen ankles, feet, or legs 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about tolterodine

How long does tolterodine take to work? 
You may notice an improvement within 1 to 2 weeks, but it can take up to 8 weeks to see full benefit[1]. 

Can I drink alcohol while taking tolterodine? 
Yes, but alcohol can make side effects like dizziness or drowsiness worse[1]. 

Will I put weight on when taking tolterodine? 
You may put weight on when taking a course of tolterodine. Speak to your pharmacist or doctor if you’re concerned[1]. 

Is tolterodine safe to use long-term? 
Yes, if monitored by your doctor or pharmacist. You may need regular reviews to check how well it is working[1]. 

Can I drive while taking tolterodine? 
Yes, unless you feel dizzy or drowsy. Do not drive until you know how the medicine affects you[1]. 

For the official NHS guide for tolterodine, visit their website.