Solifenacin

What is solifenacin used to treat?

Solifenacin is a prescription-only medicine used to treat symptoms of overactive bladder, including[1]: 

• Urgency – a sudden, strong need to urinate 

• Frequency – needing to urinate more often than usual 

• Urinary incontinence – involuntary leakage of urine caused by a sudden urge 

It also helps reduce bladder spasms and improves bladder control. 

How does solifenacin work?

Solifenacin belongs to a group of medicines called antimuscarinics. It works by blocking muscarinic receptors in the bladder wall. These receptors trigger muscle contractions, so by blocking them, solifenacin relaxes the bladder, increases its capacity, and reduces urgency and leakage[1]. 

Who can take solifenacin?

Solifenacin is suitable for most adults, but some people should avoid or use it with caution[1]. 

Do not take solifenacin if you[1]: 

• Have urinary retention (trouble emptying your bladder) 

• Have severe liver problems 

• Have narrow-angle glaucoma 

• Have a blockage in your stomach or intestines 

Caution is advised if you have[1]: 

• Kidney or liver disease 

• Myasthenia gravis 

• Heart rhythm problems 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

What is the usual dose of solifenacin?

Solfenacin comes as 5mg or 10mg tablets and as a 5mg in 5ml oral solution. Your doctor will determine the right dose for you. Typically[1]:

• The usual starting dose is 5mg once daily, which can be increased to 10mg once daily if needed. 

How to take solifenacin

To ensure maximum benefit, follow these instructions when taking solifenacin[1]:

• Take once daily, at the same time each day. 

• Can be taken with or without food. 

• Swallow the tablet whole with water – do not crush or chew it. 

• Use the syringe or spoon included to measure the liquid – do not use a kitchen teaspoon. 

Can you stop taking solifenacin?

Do not stop taking solifenacin suddenly without medical advice. Stopping can cause symptoms to return. If you're having side effects or the medicine isn't helping, speak with your doctor about possible alternatives[1]. 

What to do if you take too much solifenacin

Taking too much solifenacin can cause unwanted effects. You may experience[1]: 

• Drowsiness or confusion 

• Blurred vision 

• Faster heartbeat or difficulty urinating 

In case of an overdose, call 111 or go to A&E immediately. 

What if I miss a dose of solifenacin?

If you forget to take your tablet[1]:

• Take it as soon as you remember. 

• If it’s nearly time for your next dose, skip the missed dose. 

• Never take a double dose to make up for a missed one. 

Medicines you can and can't take with solifenacin

Some medicines may interact with solifenacin. You should avoid combining it with[1]: 

• Other anticholinergic medicines (e.g., oxybutynin, tolterodine) 

• Medicines that affect heart rhythm (e.g., amiodarone) 

• Certain antifungals (e.g., ketoconazole) 

• Some antibiotics (e.g., erythromycin) 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

Side effects of solifenacin

Solifenacin is generally well-tolerated, but some people may experience side effects. Common side effects include[1]: 

• Dry mouth 

• Constipation 

• Blurred vision 

• Urinary tract infections 

Less common but more serious side effects may include[1]: 

• Difficulty urinating 

• Severe stomach pain 

• Allergic reactions (rash, swelling, or difficulty breathing) 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2].

Frequently asked questions about solifenacin

Can I drink alcohol while taking solifenacin? 
Yes but be aware that alcohol can increase side effects like drowsiness or dizziness[1]. 

Can I drive while taking solifenacin? 
Yes, unless you experience blurred vision or dizziness. If so, avoid driving or using heavy machinery[1]. 

How long does solifenacin take to work? 
Some improvement may be noticed within a few days, but full benefit may take several weeks[1]. 

Can I take solifenacin long-term? 
Yes, it can be taken long-term if it's effective and well-tolerated. Regular reviews with your GP are advised[1]. 

Is it safe during pregnancy or breastfeeding? 
Solifenacin is not usually recommended during pregnancy or breastfeeding. Always consult your doctor[1]. 

For the official NHS guide for solifenacin, visit their website.