Pravastatin

What is pravastatin?

Pravastatin is a cholesterol-lowering medicine from the statin family. It helps reduce the risk of heart attacks, strokes, and other cardiovascular problems by lowering ‘bad’ cholesterol (LDL) and raising ‘good’ cholesterol (HDL). It is only available on prescription[1].  

What is pravastatin used for?

Pravastatin is prescribed to[1]: 

• Treat high cholesterol (hypercholesterolaemia) 

• Reduce chances of heart disease in people at high risk 

• Reduce the risk of stroke and heart attacks 

• Support those with a family history of cardiovascular disease 

• Help manage cholesterol levels after an organ transplant  

How does pravastatin work?

Pravastatin works by blocking an enzyme in the liver called HMG-CoA reductase, which the body needs to make cholesterol. This results in[1]: 

• Lower levels of LDL (low-density lipoprotein or ‘bad’ cholesterol) 

• Higher levels of HDL (high-density lipoprotein or ‘good’ cholesterol) 

• Reduced levels of triglycerides (another type of fat in the blood)   

Who can take pravastatin?

Pravastatin is suitable for adults and children over 8 years old (in certain cases) with high cholesterol or cardiovascular risk factors. You should speak to your doctor first if you[1]: 

• Have lung, kidney, or liver problems 

• Have an underactive thyroid 

• Have a muscle disorder 

• Have a history of myasthenia gravis 

• Are allergic to pravastatin or other statins 

• Are pregnant, trying to get pregnant, or breastfeeding 

• Drink large amounts of alcohol 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

What is the typical dosage of pravastatin?

Typical dosing depends on age and health status[1]: 

• Adults: 10mg to 40mg once daily 

• Children: 10mg, but may be increased depending on your child’s age 

Your dose may also be adjusted depending on how you respond to treatment[1].  

How do you take pravastatin?

To ensure effectiveness[1]: 

• Take once daily, preferably in the evening 

• Swallow tablets whole with water 

• Can be taken with or without food 

• Try to take it at the same time each day  

Can you stop taking pravastatin?

You should not stop taking pravastatin without speaking to your doctor or pharmacist. Stopping suddenly can cause your cholesterol to rise again, increasing your risk of heart attack or stroke[1].  

What do you do if you take too much pravastatin?

While serious effects from an overdose are unlikely, you should contact your GP, pharmacist, or call NHS 111. Go to A&E if you feel unwell or concerned[1]. 

What do you do if you forget to take pravastatin?

Here’s what to do[1]: 

• Take it as soon as you remember 

• If it’s nearly time for your next dose, skip the missed one 

• Do not take a double dose to make up for the missed tablet  

How do you store pravastatin?

Keep pravastatin at room temperature in a dry place in its original packaging. Ensure it’s kept out of reach of children and pets[1].  

What medicines can’t you take with pravastatin?

Some medicines may interact with pravastatin, needing to be used with caution or avoided. Speak to your doctor or pharmacist if you take[1]: 

• Other cholesterol-lowering medicines (e.g. fibrates) 

• Certain antibiotics (e.g. erythromycin, clarithromycin) 

• Antifungal medications (e.g. itraconazole) 

• Immunosuppressants (e.g. ciclosporin and HIV medication) 

• Hepatitis C medicine 

• Colchicine for gout 

• Warfarin or other blood thinners 

• Grapefruit juice – this can interfere with how statins are processed  

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of pravastatin?

Like all medicines, pravastatin can cause side effects. Common side effects include[1]: 

• Headache 

• Nausea or indigestion 

• Muscle pain or weakness 

• Tiredness 

• Cold-like symptoms 

Rare but serious side effects include[1] 

• Muscle breakdown (rhabdomyolysis) 

• Liver problems (e.g. yellowing of skin or eyes) 

• Severe allergic reactions 

Contact your doctor urgently if you develop[1]: 

• Muscle pain with dark urine 

• Unusual fatigue 

• Any signs of liver problems 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about pravastatin

How long does pravastatin take to work? 
You may notice a difference in your cholesterol levels within 4 weeks, but it is a long-term treatment[1]. 

Can I drink alcohol while taking pravastatin? 
Yes, in moderation. However, heavy drinking increases the risk of liver problems[1]. 

Can I take pravastatin during pregnancy? 
No – pravastatin should not be used during pregnancy or breastfeeding[1] 

Are there natural alternatives to pravastatin? 
Some dietary changes and supplements may help, but they are not a substitute for prescribed statins[1]. 

Can pravastatin cause weight gain? 
Weight gain is not a common side effect of pravastatin[1]. 

Is pravastatin safe for long-term use? 
Yes – most people take it safely for many years with regular monitoring[1]. 

For the official NHS guide to pravastatin, visit their website.