Perindopril

What is perindopril?

Perindopril is a prescription medicine used to treat high blood pressure and other heart-related conditions. It belongs to a group of drugs known as ACE inhibitors (angiotensin-converting enzyme inhibitors), which help relax blood vessels and reduce strain on the heart[1]. 

What is perindopril used for?

Perindopril is prescribed to[1]: 

• Lower high blood pressure (hypertension) 

• Treat heart failure 

• Support recovery after a heart attack 

• Reduce the risk of serious heart events in people with stable coronary artery disease 

How does perindopril work?

Perindopril works by blocking an enzyme that produces angiotensin II, a chemical that narrows blood vessels. By reducing levels of this substance[1]: 

• Blood vessels relax and widen 

• Blood pressure decreases 

• The heart pumps more easily and efficiently  

Who can take perindopril?

Perindopril is suitable for most adults over 18. However, it may not be suitable if you[1]: 

• Are pregnant, trying to get pregnant, or breastfeeding 

• Have kidney, liver, or heart problems 

• Are on dialysis 

• Are dehydrated 

• Have low or unstable blood pressure 

• Have had allergic reactions to ACE inhibitors 

• Are going to have a major operation or a general anaesthetic 

• Have recently had diarrhoea or vomiting 

• Are on a low-salt diet 

• Are going to have desensitisation treatment to reduce your allergy to insect stings 

• Have a blood problem like a low white blood cell count 

If you have diabetes, you should check your blood sugar (glucose) levels more often in the first few weeks of taking perindopril[1]. 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

How do you take perindopril?

You should take perindopril once daily as directed by your doctor or pharmacist. Here’s how[1]: 

• Take it 30 to 60 minutes before breakfast 

• Swallow the tablet whole with water 

• Your first dose may be taken at bedtime due to the risk of dizziness 

What is the typical dosage of perindopril?

Your dose of perindopril depends on why you need the medicine. Take it how your doctor tells you to. However, the usual dosage of[1]: 

• Perindopril erbumine is 4mg daily for high blood pressure, 8mg daily after a heart attack, or 4mg daily for heart failure 

• Perindopril arginine is 5mg daily for high blood pressure, 10mg daily after a heart attack, or 5mg daily for heart failure 

Doctors usually start with a low dose and adjust gradually depending on your response and any side effects. 

Can you stop taking perindopril?

No, do not stop taking it suddenly without consulting your pharmacist or doctor. Stopping may cause your blood pressure to rise again, increasing the risk of heart attack or stroke[1]. 

What do you do if you take too much perindopril?

If you take more than your prescribed dose[1]: 

• You may experience symptoms like dizziness, fainting, or very low blood pressure 

• Contact NHS 111, your GP, pharmacist, or go to A&E immediately 

• Take the medication packaging with you 

What do you do if you forget to take perindopril?

If you miss a dose[1]: 

• Take it as soon as you remember on the same day 

• If you remember the next day, skip the missed dose and take your usual dose as scheduled 

• Do not double up to make up for a missed dose

What medicines can’t you take with perindopril?

Perindopril may interact with several other medicines. Tell your doctor or pharmacist if you are taking[1]: 

• Painkillers such as ibuprofen or high dose aspirin (NSAID) 

• Water tablets (diuretics) like furosemide and those that affect potassium levels such as spironolactone 

• Potassium supplements or salt substitutes that contain potassium instead of sodium 

• Lithium which is used for certain mental health conditions 

• Some antidepressants, nitrates, baclofen, anaesthetics, or alpha-blockers (which are used for prostate problems) may increase the risk of your blood pressure dropping too low 

• Allopurinol for gout 

• Procainamide for heart rhythm problems 

• Immunosuppressants like ciclosporin and tacrolimus 

• Other medications for high blood pressure 

• Medicines for low blood pressure, heart failure, asthma, or allergies 

• Medicines for diabetes, including insulin and gliptins 

This list is not exhaustive. Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of perindopril?

The most common side effects of perindopril occur in more than 1 in 100 people and include[1]: 

• Dry, persistent cough – if this becomes troublesome, speak to your doctor 

• Dizziness 

• Mild skin rash 

• Blurred vision 

• Muscle cramps 

• Headache 

• Tiredness or fatigue 

• Nausea 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Severe stomach pain 

• Fainting 

• Irregular heartbeat 

• Signs of kidney problems (e.g. changes in urination) 

• Signs of liver problems (e.g. yellowing of skin or eyes) 

 If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about perindopril

How long does perindopril take to work? 
It starts working within a few hours, but full benefits may take weeks[1]. 

Can I drink alcohol while taking perindopril? 
Yes, but alcohol may increase the risk of dizziness or light-headedness[1]. 

Will I need to take perindopril for life? 
In many cases, yes – especially if used for blood pressure control or heart protection[1]. 

Is it safe during pregnancy? 
No – perindopril should not be used in pregnancy or while breastfeeding[1]. 

Do I need to avoid any foods while taking perindopril? 
Avoid salt substitutes because the potassium in these can cause your blood potassium level to be too high[1]. 

For the official NHS guide to perindopril, visit their website.