Nystatin

What is nystatin?

Nystatin is a prescription-only antifungal medicine used to treat and prevent infections caused by Candida species, a type of yeast. It belongs to the polyene class of antifungals and is most commonly available as an oral suspension, or as a topical cream combined with other medicines, under brand names like Trimovate, Timodine, Nystaform, and Nystaform HC[1]. 

What is nystatin used for?

Nystatin is commonly prescribed to treat and prevent fungal infections in different parts of the body, including[1]:

• Oral thrush (a yeast infection in the mouth and throat) 

• Intestinal candidiasis (Candida infection in the gut) 

• Skin infections caused by Candida 

• Prevention of oral thrush in newborns whose mothers have vaginal thrush 

How does nystatin work?

Nystatin works by binding to ergosterol, a vital component of fungal cell membranes. This binding creates holes in the membrane, causing the contents of the cell to leak out and ultimately leading to cell death[1]. 

Who can take nystatin?

Nystatin is suitable for a wide range of people, including[1]: 

• Adults and children, including newborns 

• Pregnant and breastfeeding women, when prescribed by a doctor 

However, you should speak to a doctor or pharmacist first if you[1]: 

• Are allergic to nystatin or any ingredient listed in the formulation 

• Cannot digest some sugars (the liquid form has a small amount of sucrose in it) 

• Cannot have alcohol as some oral suspensions contain ethanol 

• Have tuberculosis of the skin – may not be able to use cream or ointment 

• Have systemic fungal infections (e.g. infections in the lungs or bloodstream), as nystatin is not effective in these cases 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2]. 

What is the typical dosage of nystatin?

The dosage of nystatin depends on the form and condition being treated. Common regimens include[1]: 

• Oral suspension (e.g. Nystan 100,000 units/ml): 

• To treat oral thrush – 1ml four times a day with 3 hours between doses, unless told otherwise by a doctor 

• To prevent oral thrush – 1ml, once or twice a day 

• Topical cream or ointment: 

• Apply to the affected skin 2-3 times daily 

Always follow your pharmacist or doctor’s instructions and the product leaflet. 

How do you take nystatin?

Proper administration helps improve effectiveness, see the Patient Information Leaflet for further information. For the liquid[1]: 

• Shake the oral suspension bottle well before use 

• Use the provided syringe or dropper to measure the correct dose 

• Hold the liquid in your mouth for as long as possible before swallowing 

• Continue treatment for at least 48 hours after symptoms disappear to reduce the risk of the infection returning 

For creams or ointments[1]: 

• Apply it to the affected area as prescribed by your doctor. 

Can you stop taking nystatin?

You should not stop taking nystatin early, even if symptoms start to improve. Ending treatment too soon can allow the infection to return. Always complete the full course unless your doctor tells you otherwise[1]. 

What do you do if you take too much nystatin?

Since nystatin is not significantly absorbed into the bloodstream, an overdose is unlikely to be harmful. However, if a large quantity is swallowed accidentally – especially by a child – seek medical advice or contact NHS 111[1]. If your cream or ointment contains a strong steroid such as clobetasol, talk to your pharmacist or doctor.  

What do you do if you forget to take nystatin?

If you forget to take a dose of nystatin[1]: 

• Take it as soon as you remember 

• If it's almost time for your next dose (less than 3 hours), skip the missed one 

• Do not take two doses at once to make up for a missed dose 

What medicines can’t you take with nystatin?

Nystatin generally has low potential for drug interactions because it is not absorbed into the bloodstream. Even so, be cautious if you are using other antifungals or oral treatments for similar infections[1]. 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of nystatin?

Like all medicines, nystatin can cause side effects, although not everyone gets them. Common side effects include[1]: 

• Nausea 

• Diarrhoea 

• Stomach discomfort 

Rare but more serious side effects include[1]: 

• Rash, itching, or swelling 

• Breathing difficulties (this requires urgent medical attention) 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2].

Frequently asked questions about nystatin

Can I use nystatin while pregnant? 
Yes, but only if prescribed by your doctor. It is generally considered safe when used under medical supervision[1]. 

How long does it take for nystatin to work? 
Symptoms typically start to improve within a few days, but it's important to complete the entire course as prescribed[1]. 

Can I drink water after taking nystatin? 
It's best to wait at least 30 minutes after taking the oral suspension before drinking anything[1]. 

Can I use nystatin for vaginal thrush? 
No, nystatin is not commonly used for vaginal thrush in the UK. Other treatments such as clotrimazole or fluconazole are preferred[1]. 

Does nystatin affect birth control? 
No, there are no known interactions between nystatin and hormonal contraceptives[1]. 

Is nystatin safe for babies? 
Yes, it is commonly prescribed for newborns and infants with oral thrush[1]. 

Can I use nystatin long-term? 
It is typically used for short-term treatment. If you need long-term use, it should be under regular medical supervision[1]. 

For the official NHS guide to nystatin, visit their website.