Molnupiravir (Lagevrio)

What is molnupiravir?

Molnupiravir is a prescription-only oral antiviral medicine used to treat COVID-19 in people at high risk of developing severe illness. It is available in capsule form and is used to reduce the risk of hospitalisation and complications[1]. 

What is molnupiravir used to treat?

Molnupiravir is prescribed for[1]: 

• Mild to moderate COVID-19 in adults 

• Patients not requiring oxygen but at risk of developing severe symptoms 

It is not used to prevent COVID-19 or to treat patients already hospitalised with severe illness. 

How does molnupiravir work?

Molnupiravir targets the virus responsible for COVID-19 by[1]: 

• Inhibiting viral replication 

• Causing errors in the viral RNA, which prevents the virus from reproducing 

This helps your immune system clear the virus more efficiently. 

Who can take molnupiravir?

It is suitable for[1]: 

• Adults aged 18 and over 

• Those who tested positive for COVID-19 

• People within 5 days of symptom onset 

• Individuals at high risk of severe illness (e.g. elderly, immunocompromised, or with chronic conditions) 

It is not suitable for[1]: 

• Pregnant or breastfeeding individuals 

• Children under 18 

• People with allergies to any ingredients in the medication 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2]. 

What is the typical dosage of molnupiravir?

Each capsule contains 200mg of molnupiravir. Take 4 capsules (800mg) twice daily, 12 hours apart. Duration of treatment is 5 days. Capsules should be swallowed whole with water, with or without food[1]. 

How do you take molnupiravir?

To ensure the medicine works effectively[1]:

• Start as soon as possible after a positive test and within 5 days of symptom onset 

• Space doses 12 hours apart 

• Do not crush or chew the capsules 

• Complete the entire 5-day course 

Can you stop taking molnupiravir?

No. You must complete the full course, even if you feel better, to ensure the virus is fully suppressed and to reduce the risk of resistance[1]. 

What do you do if you take too much molnupiravir?

Although overdose is unlikely, it may increase the risk of side effects. Seek medical attention promptly by calling NHS 111 or your GP[1]. 

What do you do if you forget to take molnupiravir?

If you remember within 10 hours, take the missed dose and continue your schedule. If more than 10 hours have passed, skip the missed dose. Do not take two doses at once[1]. 

How do you store molnupiravir?

To store molnupiravir properly[1]:

• Keep in a cool, dry place below 25°C 

• Store in the original packaging 

• Keep out of reach of children 

• Do not use after the expiry date 

What medicines can’t you take with molnupiravir?

No major interactions are known, but always inform your doctor or pharmacist if you are taking[1]: 

• Other antivirals 

• Immunosuppressants 

• Hormonal contraceptives (additional contraception may be needed during and for 4 days after treatment) 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of molnupiravir?

Most people tolerate it well, but possible common side effects include[1]: 

• Headache 

• Dizziness 

• Nausea 

• Diarrhoea 

Avoid driving or using machinery if you feel dizzy. 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about molnupiravir

How quickly does molnupiravir work? 
It begins working shortly after the first dose[1]. 

Can I take molnupiravir if I’m vaccinated?  
Yes, if you’re in a high-risk group[1]. 

Can I take it during pregnancy? 
No, it is not recommended[1]. 

Can I take molnupiravir while breastfeeding? 
No, avoid during and shortly after use[1]. 

Can I drink alcohol? 
No interactions are known, but drink in moderation[1]. 

Can I take molnupiravir with food? 
Yes, food does not affect its effectiveness[1]. 

Is molnupiravir a cure for COVID-19? 
No, but it can reduce the risk of complications[1]. 

Do I need to isolate while taking molnupiravir? 
Follow current NHS guidance for those with COVID-19[1]. 

What if I feel better before finishing the course? 
Complete the full course regardless[1]. 

For the official NHS guide to molnupiravir, visit their website.