Medroxyprogesterone Tablets

What is medroxyprogesterone?

Medroxyprogesterone (also known as medroxyprogesterone acetate) is a synthetic progestogen, a hormone similar to natural progesterone. It is available on prescription and sold under brand names such as Provera[1]. 

What is medroxyprogesterone used for?

Medroxyprogesterone tablets are used to manage a range of hormone-related and menstrual conditions, including[1]:

• Heavy, painful, or irregular periods 

• Absence of periods (amenorrhoea) 

• Endometriosis 

• Polycystic ovary syndrome (PCOS) 

• Menopausal symptoms (as part of hormone replacement therapy, HRT) 

• Hot flushes caused by prostate cancer treatment 

• Certain cancers (at high doses of 100-400mg) 

• Injectable version given for contraception 

How does medroxyprogesterone work?

Medroxyprogesterone mimics the action of natural progesterone and helps to[1]:

• Regulate the menstrual cycle 

• Reduce abnormal uterine bleeding 

• Thin the lining of the womb 

• Counteract the effects of oestrogen in HRT 

Who can take medroxyprogesterone?

Most adult women, and girls who have started their periods, can take medroxyprogesterone. However, it should be use with caution or may not be suitable for those who[1]: 

• Are pregnant, trying to get pregnant, or breastfeeding 

• Have or have had breast cancer 

• Have a history of blood clots (e.g. DVT, stroke, pulmonary embolism) 

• Have liver disease 

• Have high blood pressure 

• Have had a heart attack or have angina 

• Have ever had mental health problems 

• Have hearing loss caused by otosclerosis 

• Have migraines, diabetes, epilepsy, asthma, gallstones, or lupus 

• Have porphyria (a rare metabolic disorder) 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2]. 

What is the typical dosage of medroxyprogesterone?

Medroxyprogesterone comes as 2.5mg, 5mg and 10mg tablets. The dose varies depending on the condition being treated[1]: 

• Period problems: 2.5mg to 10mg daily for 5 to 10 days, in two or three cycles (as prescribed) starting 16 to 21 days after your last period 

• Endometriosis: 10mg three times a day for 90 days 

• PCOS: 10mg once daily for 14 days every 1 to 3 months 

• HRT (to oppose oestrogen in those with a womb): 10 mg daily for the last 14 days of your 28-day oestrogen cycle 

Medroxyprogesterone also comes as higher strength 100mg, 200mg and 400mg tablets but only for cancer treatment[1]. 

How do you take medroxyprogesterone?

To take medroxyprogesterone safely and effectively[1]:

• Follow your doctor’s instructions exactly, as dose frequencies vary 

• Take it with or without food 

• Swallow tablets whole with water 

• Aim to take it at the same time(s) each day 

Can you stop taking medroxyprogesterone?

You should not stop taking medroxyprogesterone without medical advice[1].

• Your doctor or pharmacist may recommend a gradual reduction 

• Stopping suddenly may cause withdrawal bleeding or a return of symptoms 

What do you do if you take too much medroxyprogesterone?

If you take more than prescribed[1]:

• Call NHS 111 or contact your doctor 

• Symptoms may include nausea, vomiting, or unexpected vaginal bleeding 

What do you do if you forget to take medroxyprogesterone?

If you forget to take your dose[1]:

• Take it as soon as you remember 

• If it’s nearly time for your next dose, skip the missed one 

• Do not take a double dose 

How do you store medroxyprogesterone?

To keep your medication safe and effective[1]:

• Store below 25°C 

• Keep it in its original packaging 

• Keep out of sight and reach of children 

• Do not use after the expiry date 

What medicines can’t you take with medroxyprogesterone?

Medroxyprogesterone may interact with other medicines and so may have to be used with caution or avoided. Tell your doctor or pharmacist if you take[1]: 

• Anticonvulsants (e.g. phenytoin, carbamazepine) 

• Antibiotics (e.g. rifampicin) 

• HIV medicines (e.g. ritonavir, nelfinavir) 

• St John’s Wort 

• Warfarin, as medroxyprogesterone may affect blood clotting 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of medroxyprogesterone?

Like all medicines, medroxyprogesterone can cause side effects. Common side effects include[1]: 

• Headache 

• Nausea 

• Irregular bleeding or spotting 

• Dizziness 

• Difficulty sleeping 

• Higher body temperature 

• Tiredness 

• Itchy skin 

• Hair loss 

• Breast tenderness 

• Weight gain 

• Acne 

• Vaginal discharge 

Uncommon or rare[1]: 

• Facial hair growth 

• Fluid retention 

• Blood clots (DVT, stroke, pulmonary embolism) 

Seek urgent help if you experience[1]: 

• Chest pain or shortness of breath 

• Sudden vision or speech problems 

• Swelling or pain in one leg 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about medroxyprogesterone

Is medroxyprogesterone a contraceptive? 
When taken orally, medroxyprogesterone is not an effective form of contraception. Taking medroxyprogesterone can affect your choice of contraception and barrier methods such as condoms should be used.[1]. 

Medroxyprogesterone may be used as a contraceptive; however, it is to be administered via an injection.  

How long does medroxyprogesterone take to work? 
It starts working quickly, but full effect may take 2-3 months[1]. 

Can I take it during pregnancy? 
No. It should not be taken if you’re pregnant[1]. 

Can I take medroxyprogesterone while breastfeeding? 
Not usually. Wait at least 6 weeks postpartum and check with your doctor[1]. 

Will it affect my fertility? 
Fertility may be delayed after stopping, but it usually returns[1]. 

Can I drink alcohol with medroxyprogesterone? 
Yes – in moderation. There are no known interactions[1]. 

Does it cause weight gain? 
Yes, especially at higher doses[1]. 

Can I drive or use machines on medroxyprogesterone? 
Usually safe but you should always avoid driving if you feel dizzy[1]. 

Can I take medroxyprogesterone with HRT? 
Yes – it’s often prescribed alongside oestrogen as protection against womb cancer[1]. 

For the official NHS guide to medroxyprogesterone tablets, visit their website.