Mebeverine

What is mebeverine used for?

Mebeverine is an antispasmodic medicine used to relieve symptoms of irritable bowel syndrome (IBS) and other digestive conditions. It works by relaxing the muscles in your gut and easing painful cramps. It’s also known by brand names Colofac and Aurobeverine[1]. 

It’s commonly used to treat[1]: 

• Irritable Bowel Syndrome (IBS) 

• Gastrointestinal disorders involving smooth muscle spasms 

It helps relieve[1]: 

• Abdominal cramps 

• Bloating and flatulence 

• Diarrhoea or constipation (or alternating between both)

How does mebeverine work?

Mebeverine works by relaxing the smooth muscle in the walls of your intestines. This helps reduce painful spasms without affecting normal bowel movements. It can help restore a more regular digestive rhythm and ease discomfort caused by overactive gut muscles[1].

Who can take mebeverine?

Mebeverine is suitable for most adults and children over 10 years old, while it is sometimes prescribed for children aged 3 and over[1]. 

It may not be suitable if you[1]: 

• Have severe constipation 

• Are unable to digest galactose (the sugar found in lactose) 

• Have paralytic ileus (a rare condition where your bowel stops working properly) 

• Are allergic to mebeverine or any of its ingredients 

You should speak to your doctor if you're pregnant, breastfeeding, or have concerns about taking this medicine. 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].

What is the typical dosage of mebeverine?

Mebeverine is available in several forms, including[1]: 

• Tablets (135mg): Take one tablet three times a day, ideally 20 minutes before meals 

• Slow-release capsules (200mg): Take one capsule twice a day 

• Liquid: For people who have difficulty swallowing tablets, please follow your doctor’s instructions 

Always follow the instructions provided with your medicine or as directed by your doctor.

How do you take mebeverine?

Follow your doctor or pharmacist’s instructions, but you should usually[1]: 

• Swallow the tablets or capsules whole with water – do not chew them 

• Take 20 minutes before meals to help prevent symptoms starting 

• Try to take it at the same time(s) each day for best effect 

Can you stop taking mebeverine?

Yes – you can stop taking mebeverine once your symptoms improve. It is not addictive and doesn't require tapering off. If symptoms return, you can start taking it again[1]. 

What do you do if you take too much mebeverine?

Taking too much mebeverine is unlikely to be harmful, but may cause[1]: 

• Headaches 

• Dizziness 

• Nausea 

If you’re concerned or feel unwell, contact your doctor or NHS 111 for advice.

What if you forget to take a dose of mebeverine?

If you forget a dose take it as soon as you remember, but if it’s nearly time for your next dose, skip the missed one. Never double up to make up for a missed dose[1]. 

Medicines you can and can’t take with mebeverine

Mebeverine is generally safe to take with most medicines. However, tell your doctor or pharmacist if you are also taking[1]: 

• Other antispasmodics 

• Other IBS medication or laxatives 

• Herbal remedies or supplements 

There are no major known drug interactions, but it’s always good practice to inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2].

What are the side effects of mebeverine?

Mebeverine is usually well tolerated. Side effects are rare but may include[1]: 

• Mild skin rash or itching (sign of an allergic reaction) 

• Swelling of the face, lips, or throat (seek immediate help) 

• Dizziness or headaches (uncommon) 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include: 

• Difficulty breathing 

• Tightness in throat and chest 

• Swelling of the tongue or throat 

• Feeling faint or dizzy 

• Blue/grey skin or lips 

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2].

Frequently asked questions about mebeverine

Can I drink alcohol while taking mebeverine? 

Yes. Alcohol does not interact with mebeverine, but it may worsen IBS symptoms in some people[1]. 

How long does it take to work? 

You may notice improvement within a few hours or days. Full relief may take longer depending on your condition[1]. 

Can I take mebeverine long-term? 

Yes, it's safe to take as needed during flare-ups or on a regular basis if advised by your doctor[1]. 

Is it safe during pregnancy or breastfeeding? 

Only take it if your doctor says it's necessary. It’s generally avoided in pregnancy unless the benefits outweigh the risks[1]. 

Will mebeverine affect my contraception? 

No, mebeverine does not affect any type of contraception[1]. 

For the official NHS guide to mebeverine, visit their website.