Lidocaine Skin Cream

What is lidocaine skin cream?

Lidocaine skin cream is a topical local anaesthetic used to numb the surface of the skin before minor procedures. It works by blocking nerve signals and reducing pain. It is available on prescription and for purchase in pharmacies to use with cosmetic procedures involving a needle. Common brand names include Denela, Nulbia, EMLA Cream (lidocaine & prilocaine), and LMX4 Cream (lidocaine 4%)[1]. 

What is lidocaine skin cream used for?

This cream is used for a range of purposes, including[1]: 

• Numbing the skin before injections, blood tests, minor procedures, or laser treatments 

• Reducing pain during tattoo removal or wart removal 

• Pain relief for leg ulcers (under medical supervision) 

• Occasionally, numbing the genital area before procedures (under medical supervision) 

How does lidocaine skin cream work?

Lidocaine blocks sodium channels in nerves, which prevents pain signals from being sent to the brain. The numbing effect usually starts within 30 to 60 minutes and can last for up to 2 hours, depending on the product and how long it is left on[1]. 

Who can take lidocaine skin cream?

Lidocaine cream is suitable for most adults and children, but not everyone. It may not be suitable for[1]: 

• People allergic to lidocaine, prilocaine, or other local anaesthetics or any ingredient listed as part of your medicine 

• Infants under 1 month (LMX4) or under 12 months (EMLA, if taking other medications) 

• People with conditions such as G6PD deficiency or methaemoglobinaemia 

• People who have cuts, rashes, eczema, bleeding, or scabs in the area where the cream is to be used 

• Application to the middle ear 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

How do you take lidocaine skin cream?

To apply lidocaine skin cream safely and effectively follow the instructions provided by your healthcare professional or follow the directions in the Patient Information Leaflet. For example, when using EMLA cream[1]: 

• Apply a thick layer to an area of clean, dry skin e.g. where the needle will be put in 

• Do not rub it in 

• Cover with an occlusive dressing (plastic wrap or supplied cover) 

• Leave on for 30 to 60 minutes 

• Remove the dressing and wipe off the cream before the procedure 

What is the typical dosage of lidocaine skin cream?

The amount used depends on the procedure you're having and the type of cream you’re using. Follow the instructions that come with the lidocaine or from your doctor, nurse, or pharmacist. You might need to use the whole tube, more than 1 tube, or just part of a tube[1].  

Can you stop taking lidocaine skin cream?

Yes, lidocaine cream is used as needed. You can stop using it once pain relief is no longer required[1]. 

What do you do if you take too much lidocaine skin cream?

Using too much can increase the risk of side effects such as[1]: 

• Dizziness 

• Blurred vision 

• Irregular heartbeat 

• Seizures (rare) 

Seek medical help immediately if an overdose is suspected[1]. 

What do you do if you forget to take lidocaine skin cream?

Apply it as soon as you remember, making sure there is enough time before the procedure. 
If there isn’t enough time, inform your healthcare provider[1]. 

How do you store lidocaine skin cream?

Store lidocaine cream correctly to ensure it remains effective[1]: 

• Store at room temperature 

• Keep out of reach of children 

• Do not use after the expiry date 

• Use within 6 months of opening (for LMX4) 

What medicines can’t you take with lidocaine skin cream?

Lidocaine may interact with other medicines, however it is more likely if you’re using a high dose or if you’re having lidocaine injections. Use caution if you are taking[1]: 

• Other local anaesthetics 

• Medicine used to prevent or treat an irregular heartbeat such as amiodarone 

• Sulphonamides or nitrofurantoin 

• Phenytoin or phenobarbital 

• Cimetidine or beta-blockers (can increase lidocaine levels) 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of lidocaine skin cream?

Lidocaine cream can cause side effects, though they are usually mild[1]. 

Common (up to 1 in 10 people): 

• Redness 

• Mild stinging or burning 

• Itching 

• Skin whitening (EMLA) or redness (Ametop) 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about lidocaine skin cream

How long does lidocaine skin cream take to work? 
Usually 30 to 60 minutes[1]. 

How long does the numbness last? 
Typically 1 to 2 hours after the cream is removed[1]. 

Can I use lidocaine skin cream on broken skin? 
Only if advised by a doctor or pharmacist – e.g. for leg ulcers[1]. 

Can I use it on children? 
Yes, but dose and age restrictions vary. Check the leaflet[1]. 

Can I use lidocaine skin cream before waxing or tattoos? 
Yes but follow the instructions carefully and don’t overuse[1]. 

Can I use it on my face? 
Yes, but avoid the eyes, nose, and mouth[1]. 

Can I use lidocaine skin cream during pregnancy? 
Occasional use is generally considered safe. Ask your doctor[1]. 

Can I use it with other pain relief? 
Possibly. Speak to your pharmacist or doctor first[1]. 

What if I get a rash or reaction? 
Stop using the cream and seek medical advice[1]. 

For the official NHS guide to lidocaine, visit their website.