Indapamide

What is indapamide?

Indapamide is a thiazide-like diuretic, often called a water tablet, and commonly known by the brand names Natrilix, Indipam, Rawel, Tensaid, and Alkapamid. It is commonly used to treat high blood pressure (hypertension) and fluid retention (oedema). By helping your body get rid of excess salt and water through urine, Indapamide lowers blood pressure and eases the strain on your heart[1].  

What is indapamide used to treat?

Indapamide is prescribed to treat[1]: 

• High blood pressure (hypertension) 

• Heart failure 

• The build up of fluid in the body (oedema) 

How does indapamide work?

Indapamide lowers blood pressure and reduces fluid buildup through two main actions[1]: 

• It helps your kidneys remove excess salt and water via urine. 

• It relaxes blood vessels, making it easier for blood to flow and lowering overall pressure. 

Who can take indapamide?

Indapamide is suitable for many adults aged 18 and over, but it’s not appropriate for everyone. 

It may be suitable for people with[1]: 

• High blood pressure 

• Fluid retention 

It may not be suitable for people who[1]: 

• Are allergic to indapamide or other sulfonamide medicines 

• Have severe kidney or liver problems 

• Have low potassium or sodium levels 

• Are pregnant or breastfeeding (unless advised by a doctor) 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

What is a typical dose of indapamide?

Indapamide dosage depends on the condition being treated. It comes as 2.5mg standard tablets, and as 1.5mg slow-release tablets.  Typical doses include[1]: 

• High blood pressure: 2.5mg, taken once a day as standard tablets, or 1.5mg once a day as slow-release tablets 

• Heart failure: 2.5mg to 5mg, taken once a day as standard tablets 

Always follow your doctor’s prescription and never adjust the dose yourself. 

How to take indapamide

Here’s how to take indapamide for best results[1]: 

• Take it once a day, ideally in the morning (to avoid nighttime trips to the toilet) 

• Swallow the tablet whole with water 

• Can be taken with or without food 

Can you stop taking indapamide?

You should not stop indapamide suddenly without medical advice[1]: 

• Stopping may cause your blood pressure to rise again or fluid to accumulate 

• If you're having side effects, talk to your doctor about alternatives 

What to do if you take too much indapamide?

Taking too much indapamide can be dangerous. Overdose symptoms may include[1]: 

• Dizziness or fainting (low blood pressure) 

• Nausea or confusion 

• Weakness or dehydration 

Seek emergency medical help or call NHS 111 if you’ve taken too much. 

What to do if you forget a dose of indapamide?

If you miss a dose[1]: 

• Take it as soon as you remember 

• If it’s nearly time for your next dose, skip the missed one 

• Do not double the dose 

Medicines you can and can’t take with indapamide

Indapamide can interact with other medicines. Caution is needed with[1]: 

• Lithium: Can increase toxicity risk 

• NSAIDs (e.g. ibuprofen): May reduce the effectiveness of indapamide 

• Other blood pressure medicines: Can cause too much blood pressure drop 

• Other diuretics: Can increase the risk of dehydration or low potassium 

• Steroids: May lower potassium levels further 

• Certain antidepressants: Can increase risk of low sodium 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

Side effects of indapamide

As with any medication, indapamide can cause side effects. Common side effects include[1]: 

• Low potassium levels, which can cause muscle cramps or weakness 

• Headache 

• Dizziness, especially when standing quickly 

• Increased urination 

Serious but rare side effects may include[1]: 

• Irregular heartbeat 

• Severe allergic reactions 

• Liver problems (e.g., yellowing of the skin or eyes) 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include:   

• Difficulty breathing   

• Tightness in throat and chest   

• Swelling of the tongue or throat   

• Feeling faint or dizzy   

• Blue/grey skin or lips   

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about Indapamide

Can I drink alcohol with indapamide? 
Yes, but drink in moderation. Alcohol may increase dizziness[1]. 

Can I drive while taking indapamide? 
If you feel dizzy or lightheaded, avoid driving or operating machinery[1].  

Will I need regular tests? 
Yes. You’ll need routine blood tests to monitor potassium levels and kidney function[1]. 

Is indapamide safe long-term? 
Yes, if monitored regularly by your doctor[1]. 

For the official NHS guide for indapamide, visit their website.