Fexofenadine

What Is fexofenadine?

Fexofenadine is a non-drowsy antihistamine used to relieve allergy symptoms. It belongs to the second generation of antihistamines, meaning it is less likely to cause drowsiness compared to older types[1]. 

What Is fexofenadine used for?

Fexofenadine is commonly used to treat[1]: 

• Hay fever (seasonal allergic rhinitis) 

• Conjunctivitis (red, itchy eyes) 

• Eczema 

• Hives (urticaria), including chronic idiopathic urticaria 

• Reactions to insect bites and stings 

• Some food allergies 

How does fexofenadine work?

Fexofenadine works by blocking histamine, a substance released by your body when you come into contact with an irritant or allergen. This leads to symptoms like sneezing, itching, and swelling. Fexofenadine prevents these effects by blocking the histamine[1]. 

Who can take fexofenadine?

Fexofenadine is available on prescription for adults and children aged 6 and over. Fexofenadine 120mg is also available to buy for adults and children over 12 years. You can also buy fexofenadine 180mg for treatment of hives from pharmacies [1]. 

Fexofenadine may not be suitable for everyone. Please discuss with your doctor or pharmacist if you have heart, kidney or liver problems, or if you have had an allergic reaction to fexofenadine or another medicine. You must also tell your doctor or pharmacist if you are pregnant or breastfeeding[1]. 

Please tell your doctor or pharmacist about any conditions you may have before starting fexofenadine, and always follow the instructions in the Patient Information Leaflet[2]. 

How do you take fexofenadine?

Fexofenadine is usually taken once daily, ideally before a meal[1]. Tablets should be swallowed whole with water and not with orange, apple or grapefruit juice as these can reduce the effects of the medicine. 

What is the typical dose of fexofenadine?

• For Adults and children 12+[1]: 

• 120 mg once daily for hay fever 

• 180 mg once daily for hives 

• Children under 12[1]:  

• Usually a lower dose twice daily, as prescribed by a doctor 

Always follow the dosage instructions on the label or from your doctor. 

Can you stop taking fexofenadine?

Yes. You can stop taking it when you no longer need it[1]. However, if you're taking it regularly for chronic conditions like urticaria, consult your doctor before stopping. 

What do you do if you take too much fexofenadine?

If you take more than the recommended dose, it is unlikely to harm you[1]. However, you may feel dizzy, sleepy, have a fast heartbeat, or dry mouth. If you’re concerned, please call 111 or speak to your GP.  

What do you do if you forget to take fexofenadine?

If you miss a dose, take it as soon as you remember[1]. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Never take a double dose to make up for a forgotten dose.  

What are the side effects of fexofenadine?

The most common side effects include[1]: 

• Headache 

• Drowsiness or tiredness 

• Nausea 

• Dizziness 

Rare but serious side effects[1]: 

• Allergic reactions (rash, swelling, difficulty breathing) 

Call 999 or go to A&E immediately if you think you are having a serious allergic reaction. 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice.

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Medicines you can’t take with fexofenadine

You should always check with your pharmacist or GP if you’re taking other medicines including[1]: 

• Antacids containing aluminium or magnesium (leave 2 hours between taking Fexofenadine and any remedy that contains aluminium or magnesium) 

• Any medicine that makes you drowsy or gives you a dry mouth 

• Alcohol (can increase drowsiness) 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

Frequently asked questions about fexofenadine

Is fexofenadine safe during pregnancy? 

It’s best to consult your doctor. It’s usually not recommended and other antihistamines may be more suitable[1]. 

Can I drive while taking fexofenadine? 

It’s a non-drowsy antihistamine, but some people may still feel sleepy. Avoid driving if you are affected[1]. 

Is fexofenadine available over the counter? 

Yes, 120 mg tablets are available without a prescription in the UK for adults and children over 12. Higher strength 180mg tablets are available from pharmacies for adults over 18 for treatment of hives[1]. 

Can I drink alcohol while taking fexofenadine? 

It is best to avoid alcohol while you are taking Fexofenadine, as it can make you sleepy[1]. 

Can I take two different antihistamines together? 

Do not take two antihistamines together unless the doctor advises you to[1]. 

Can I take fexofenadine with other hay fever treatments? 

Yes, it’s fine to take fexofenadine with other hay fever treatments such as steroid nasal sprays or eye drops[1]. 

For the official NHS guide to fexofenadine, visit their website.