Ezetimibe

What is ezetimibe used for?

Ezetimibe is a prescription medication used to lower cholesterol levels. It belongs to a group of medicines called cholesterol absorption inhibitors and is commonly sold under the brand name Ezetrol in the UK[1]. 

It is prescribed for[1]: 

• High cholesterol (hypercholesterolaemia) 

• Mixed dyslipidaemia (abnormal lipid levels) 

• Homozygous familial hypercholesterolaemia (a rare inherited condition) 

Doctors may prescribe ezetimibe when lifestyle changes (like diet and exercise) aren't enough.  

You may also be prescribed ezetimibe if you cannot take cholesterol-lowering medicines called statins, or if a statin medicine does not work for you. It can also be used alone or alongside statins for better results. Ezetimibe also comes mixed with other medicines, like simvastatin, a type of statin known by the brand name Inegy, or bempedoic acid, known as Nustendi[1]. 

How does ezetimibe work?

Ezetimibe works by reducing the absorption of cholesterol in the small intestine. This leads to less cholesterol entering your bloodstream and helps lower LDL (bad) cholesterol levels. It usually works within 1 to 2 weeks[1]. 

Who can take ezetimibe?

Most adults and children over 10 years old can take ezetimibe. However, it may not be suitable for people who[1]: 

• Have moderate to severe liver problems 

• Are pregnant or breastfeeding (especially if taken with statins) 

• Experience unexplained muscle pain or weakness 

• Are allergic to ezetimibe 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

What is the typical dosage of ezetimibe?

The standard dose of ezetimibe for both adults and children is a 10mg tablet once daily. You can take it with or without food. If prescribed with a statin, follow your doctor’s specific guidance[1]. 

How do you take ezetimibe?

Ezetimibe is taken as a tablet. You should[1]: 

• Swallow it whole with a glass of water 

• Try to take it at the same time each day 

• Take it with or without meals 

Can you stop taking ezetimibe?

Do not stop taking ezetimibe without speaking to your doctor. Usually, treatment with ezetimibe is for life and you need to continue to take it for the medicine to work. Stopping the medicine can cause your cholesterol levels to rise again, increasing your risk of heart-related issues[1]. 

What do you do if you take too much ezetimibe?

Taking too much ezetimibe is unlikely to cause serious harm, particularly if it’s just one or two tablets. However, how much ezetimibe that can lead to an overdose depends on the person, so if you experience severe stomach pain, severe diarrhoea, or any other unusual symptoms you should contact your doctor or pharmacist, or call NHS 111 for advice[1]. 

What do you do if you forget to take ezetimibe?

If you forget to take your dose of ezetimibe, you should[1]: 

• Take it as soon as you remember 

• Skip the missed one if it’s nearly time for your next dose 

• Never take two doses at once 

What medicines can’t you take with ezetimibe?

Ezetimibe can interact with some medicines. Caution is needed if you are taking[1]: 

• Other cholesterol medication like statins (may increase the risk of muscle problems) 

• Fibrates like fenofibrate (can increase side effects) 

• Ciclosporine (may raise ezetimibe levels in the blood) 

• Antacids (can reduce its absorption – take them at different times) 

• Blood clot medication like warfarin 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2].  

What are the side effects of ezetimibe

The most common side effects may include[1]: 

• Diarrhoea 

• Abdominal pain 

• Tiredness 

• Flatulence 

Rare but more serious side effects may include[1]: 

• Muscle pain or weakness (especially if taken with a statin 

• Please seek immediate medical help if muscle pain occurs (risk of rhabdomyolysis, a serious condition involving muscle breakdown that can lead to kidney damage) 

• Liver issues (your doctor may monitor this with blood tests) 

• Severe stomach pain 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1].

Symptoms of anaphylaxis include:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about ezetimibe

Can I drink alcohol while taking ezetimibe? 

Yes, but it’s best to drink in moderation. Excessive alcohol can affect your liver, especially if you're also on statins[1]. 

How long does it take to work? 

You may see effects in as little as 2 weeks, but full benefits are usually seen after 4-6 weeks[1]. 

Will taking ezetimibe affect my contraception? 

Ezetimibe doesn’t affect common types of contraception such as the progestogen-only pill or combined pill. However, it may do so if ezetimibe causes you to have severe diarrhoea for over 24 hours[1]. 

Is ezetimibe a statin? 

No. It works differently but can be taken with a statin for added effect at the recommendation of your doctor or pharmacist[1]. 

Can I take ezetimibe long-term? 

Yes, it’s considered safe for long-term use under medical supervision[1]. 

Can I drive or ride a bike while taking ezetimibe? 

Yes, you can drive or ride a bike[1]. 

For the official NHS guide to ezetimibe, visit their website.