Edoxaban

What is edoxaban?

Edoxaban (available under the brand name Lixiana) is a type of anticoagulant. This is also known as a blood thinner. It helps prevent and treat blood clots by reducing the blood’s ability to clot[1].

What is edoxaban used for?

Edoxaban is prescribed to people who have had a health problem caused by blood clots, like a stroke or heart attack. It’s also used to prevent stroke and blood clots in people with non-valvular atrial fibrillation. This is an irregular heartbeat not caused by a heart valve problem. In other cases, edoxaban can also treat deep vein thrombosis (DVT) and pulmonary embolism (PE), and be used to prevent these conditions from recurring[1]. 

How does edoxaban work?

Edoxaban blocks Factor Xa. This is an enzyme that plays a key role in the blood clotting process. But instead, by inhibiting this enzyme, edoxaban slows down clot formation and reduces the risk of harmful blood clots[1]. 

Who can take edoxaban?

Edoxaban is suitable for most adults to take. However, it may not be appropriate for people who have active bleeding or are at high risk of bleeding. It’s also generally not used in those who have severe liver or kidney disease, a spinal injury or have had a recent spinal surgery, a stomach ulcer, antiphospholipid syndrome, had heart valve surgery, are pregnant or breastfeeding (unless advised by a doctor), are allergic to edoxaban, or are taking medications that may interact with edoxaban[1].  

Please tell your doctor or pharmacist about any conditions you may have before you start treatment and always follow the instructions in the Patient Information Leaflet[2]. 

How do you take edoxaban?

Edoxaban is taken once daily at the same time each day. It should be swallowed whole with water – with or without food – without crushing or chewing the tablet. This allows for the best absorption and results[1]. 

What is the typical dosage of edoxaban?

The usual recommended dose of edoxaban is 60mg once daily. Alternatively, a reduced dose of 30mg once daily may be prescribed for people who are taking certain medicines or have specific medical situations. Whatever your prescription, always follow the dosage instructions given by your doctor[1]. 

Can you stop taking edoxaban suddenly?

No, you should not stop taking edoxaban without first getting medical advice. Stopping it suddenly can bring the potential for serious conditions, including having a stroke or developing a blood clot. So, if you need to stop edoxaban, such as before surgery or a dental procedure, your doctor will tell you how to do this safely[1]. 

What should you do if you take too much edoxaban?

If you take too much edoxaban, it’s important to get medical attention straight away. An overdose can increase the risk of bleeding – signs of this may include unusual bruising, nosebleeds, or bleeding gums. If you’re in any doubt, get immediate medical advice[1]. 

What should you do if you forget a dose of edoxaban?

If you miss a dose of edoxaban take it as soon as you remember on the same day. If it is already the next day, skip the missed dose and continue with your regular schedule. Do not take two doses at once[1]. 

What medicines should you avoid while taking edoxaban?

Edoxaban can bring unwanted effects if it’s taken with some medicines, including[1]: 

• Other anticoagulants such as warfarin or heparin 

• Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen 

• Antidepressants such as SSRIs or SNRIs (e.g. sertraline, venlafaxine) 

• Certain antifungals and antibiotics such as ketoconazole or erythromycin 

• Irregular heartbeat medication, like verapamil or dronedarone 

• Organ rejection medication, like ciclosporin 

• Epilepsy medication like carbamazepine or phenobarbital 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of edoxaban?

When you take edoxaban, the most common side effects are unusual bleeding – such as nosebleeds, bruising, or bleeding gums – as well as anaemia and nausea[1].  

There is also the potential for more serious side effects. These can include prolonged or heavy bleeding, seeing blood in your urine or stools, or having severe headache or dizziness (which may indicate internal bleeding).  

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about edoxaban

Can I drink alcohol while taking edoxaban? 

You can drink alcohol while taking edoxaban – but it’s important to do so in moderation. This is because drinking too much alcohol can increase your risk of bleeding[1]. 

Can I have surgery or dental work while on edoxaban? 

Yes, you can have other surgeries while on edoxaban, but you should tell your doctor and dentist beforehand to make sure everything is done safely. You may also need to stop taking edoxaban temporarily while you undergo the procedure[1]. 

Is edoxaban safe during pregnancy or breastfeeding? 

Edoxaban is generally not recommended while pregnant or breastfeeding, unless specifically advised by a specialist[1]. 

Do I need regular blood tests while on edoxaban? 

Routine blood tests are not usually required with edoxaban, unlike with other medicines, such as warfarin[1]. 

For the official NHS guide to edoxaban, visit their website.