Dipyridamole

What is dipyridamole?

Dipyridamole is a prescription-only medicine used in combination with other medications to prevent blood clots. It’s often prescribed to reduce the risk of stroke or other complications in people with heart or blood vessel conditions. It is available under brand names such as Attia, and it’s sometimes combined with aspirin in a single capsule for added protection[1]. 

What is dipyridamole used for?

This medicine is commonly prescribed for several clot-related conditions. It is used to[1]: 

• Prevent blood clots in people who have had heart valve replacement surgery. 

• Reduce the risk of stroke in those who have experienced a transient ischaemic attack (TIA), often referred to as a ‘mini-stroke’. 

• Assist in heart stress testing when given as an injectable form, typically in hospital settings. 

How does dipyridamole work?

Dipyridamole helps prevent clots in two ways. It stops platelets (the cell-like structures involved in clotting) from clumping together and forming dangerous clots, and it also widens blood vessels to improve circulation and reduce pressure within the cardiovascular system[1].  

Who can take dipyridamole?

Dipyridamole is generally safe for most adults, but certain individuals should avoid it or use it only under medical supervision. You should speak to a doctor if you[1]: 

• Have low blood pressure 

• Have ever had an allergic reaction to dipyridamole 

• Have myasthenia gravis 

• Have bleeding disorders 

• Have low blood pressure 

• Have migraines 

• Suffer from unstable angina or have recently had a heart attack 

• Have liver disease or myasthenia gravis 

• Are pregnant, trying to get pregnant, or breastfeeding (unless advised by a doctor) 

Dipyridamole is rarely prescribed to children unless under the care of a specialist, usually to treat a rare condition called Kawasaki disease or to prevent blood clots after heart surgery[1]. 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

What is the typical dosage of dipyridamole?

The standard dipyridamole dose for slow-release capsules is 200mg, taken twice daily. The standard dose for tablets and liquid is 300mg to 600mg daily, divided into 3 or 4 smaller doses. Some people may take it as part of a combination capsule with aspirin. Always follow the specific instructions on your prescription label and speak with your doctor if you’re unsure[1]. 

How do you take dipyridamole?

Dipyridamole should be taken with or after food to reduce the chance of an upset stomach. Swallow the capsules or tablets whole with water, but do not chew or crush it. Use the spoon or syringe provided for the liquid form. Try to take it at the same times each day to maintain consistent levels in your body[1]. 

Can you stop taking dipyridamole?

Do not stop taking dipyridamole without talking to your doctor or pharmacist. Suddenly stopping it may increase your risk of having a stroke or developing a blood clot. If you’re experiencing side effects or have concerns, your doctor may suggest alternatives or adjustments[1]. 

What do you do if you take too much dipyridamole?

An overdose of dipyridamole can lead to symptoms like dizziness, light-headedness, or chest pain. If you suspect you’ve taken too much, call NHS 111 or go to A&E immediately[1]. 

What do you do if you forget to take dipyridamole?

If you miss a dose, take it as soon as you remember. However, if it's nearly time for your next scheduled dose, skip the missed one and continue with your usual routine. Never double your dose to make up for a missed one[1]. 

How do you store dipyridamole?

Store it at room temperature in the container in came in, and out of reach of children[1].   

What medicines can’t you take with dipyridamole?

Dipyridamole can interact with certain medicines, so it’s important to check with your doctor or pharmacist first if you are taking[1]: 

• Aspirin or other blood thinners (e.g., clopidogrel, ticagrelor, warfarin, dabigatran, apixaban, or rivaroxaban) 

• Theophylline (used for asthma or breathing problems) 

• Antacids, as they may reduce absorption, and other indigestion medicines 

• Myasthenia gravis medication 

• Other heart or blood pressure medicines (e.g., bisoprolol, ramipril, or furosemide) 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of dipyridamole?

Like all medicines, dipyridamole can cause side effects, although not everyone experiences them. Common side effects include[1]: 

• Headache 

• Dizziness 

• Nausea or stomach upset 

• Diarrhoea 

• Flushing (a feeling of warmth or redness in the face) 

Serious but rare side effects may include[1]: 

• Chest pain 

• Shortness of breath 

• Liver issues (signs include yellowing of the skin or eyes) 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about dipyridamole

How long will I need to take dipyridamole? 
Most people take it long-term, depending on their condition and response to treatment[1]. 

Can I drink alcohol while taking dipyridamole? 
Yes, in moderation. However, alcohol can make dizziness worse for some people[1]. 

Can I drive while on dipyridamole? 
You can drive if you feel well. If you experience dizziness, avoid driving or operating machinery[1]. 

Is dipyridamole safe during pregnancy? 
It’s not usually recommended unless specifically prescribed – consult your pharmacist or doctor[1]. 

Can I take dipyridamole with aspirin? 
Yes, many people take a combined capsule that includes both medicines. Do not combine them without your pharmacist or doctor’s advice[1]. 

Does dipyridamole interact with herbal remedies? 
Possibly. Some supplements can interfere with dipyridamole. Always check with your pharmacist[1]. 

For the official NHS guide to dipyridamole, visit their website.