Calcipotriol

What is calcipotriol?

Calcipotriol is a prescription-only topical treatment for plaque psoriasis. It is a synthetic form of vitamin D and works by regulating the growth of skin cells. It is available under brand names such as Dovonex and is part of a group of medicines known as anti-psoriatics[1].  

What is calcipotriol used for?

Calcipotriol is prescribed primarily to manage plaque psoriasis, the most common type of psoriasis. This condition leads to thick, scaly, and itchy patches on areas like the elbows, knees, scalp, and lower back[1].  

How does calcipotriol work?

Psoriasis is caused by the overproduction of skin cells. Calcipotriol helps to[1]: 

• Slow down the rapid growth of skin cells 

• Reduce inflammation and redness 

• Minimise the thickness and scaling of psoriatic plaques 

Who can take calcipotriol?

Calcipotriol is suitable for most adults and some children. Adults can use the ointment or scalp solution. Children aged 6 and over may only use the ointment under medical guidance. You should speak to your doctor first if you[1]: 

• Are allergic to calcipotriol 

• Have high calcium or vitamin D levels 

• Have severe kidney or liver disease 

• Are undergoing UV light therapy 

• Have pustular or erythrodermic psoriasis 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

What is the typical dosage of calcipotriol?

Calcipotriol scalp solution contains 0.05mg in 1ml. The ointment contains 0.05mg in 1g. The recommended maximum weekly dose depends on age and product type[1]: 

• Scalp solution: up to 60ml (3mg) per week 

• Ointment: 

• Adults: up to 100g per week 

• Children 12-17: up to 75g per week 

• Children 6-11: up to 50g per week 

If using the scalp application together with the ointment, do not exceed more than 5mg per week. For example: 

• 60ml scalp solution with 40ml ointment 

• 40ml scalp solution with 60ml ointment [1].  

How do you take calcipotriol?

To use calcipotriol effectively[1]: 

• Apply once or twice daily, leaving 8-12 hours between applications 

• Wash your hands after use 

• Do not apply to the face, healthy skin, or broken areas 

• Wait 30 minutes between applying other topical treatments 

Can you stop taking calcipotriol?

You can stop using calcipotriol once your psoriasis improves. Your doctor or pharmacist will advise you on when to stop, as prolonged use may raise calcium levels in the blood[1].  

hat do you do if you take too much calcipotriol?

Overuse of calcipotriol may cause symptoms of high calcium, including[1]: 

• Nausea or constipation 

• Thirst 

• Frequent urination 

• Muscle weakness or tiredness 

Seek medical advice or call 111 if these occur.  

What do you do if you forget to take calcipotriol?

Apply as soon as you remember, unless it’s within 8 hours of your next dose. Do not apply a double dose to make up for a missed one[1]. 

How do you store calcipotriol?

To store calcipotriol safely[1]: 

• Keep below 30°C 

• Avoid heat and open flames (especially for foam preparations) 

• Discard after the expiry date or six months after opening (for foams) [6]  

What medicines can’t you take with calcipotriol?

You should avoid medicines and supplements that raise calcium levels. Speak to your doctor first if you take or have recently taken]: 

• Thiazide diuretics (e.g., bendroflumethiazide) 

• Vitamin D or calcium supplements 

• Oestrogens or anabolic steroids 

• Parathyroid hormone analogues 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of calcipotriol?

Like all medicines, calcipotriol may cause side effects. Common side effects include[1]: 

• Skin irritation such as redness, dryness, or itching 

• Burning or stinging sensation 

• Temporary worsening of psoriasis 

Rare but serious side effects may include[1]: 

• High calcium levels in the blood which may present as[1]: 

• Needing to pee more often 

• Increased thirst 

• Loss of appetite 

• A dry mouth or metallic taste 

• Weakness or pain in muscles or bones 

• Headache 

• Stomach pain 

• Nausea 

• Constipation 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about calcipotriol

How long does calcipotriol take to work? 
You may start to see improvements within two weeks, with full benefits appearing by 12 weeks[1]. 

Can I use calcipotriol on my face? 
No, it is not recommended for facial use as it may cause irritation[1]. 

Can I drink alcohol while using calcipotriol? 
Yes, alcohol has no known interactions with calcipotriol[1]. 

Can I use moisturisers with calcipotriol? 
Yes but wait at least 30 minutes between applications to avoid dilution[1]. 

Can I use calcipotriol long-term? 
Only under medical supervision, as long-term use increases the risk of side effects[1]. 

Is calcipotriol safe during pregnancy or breastfeeding? 
Consult your doctor before using calcipotriol if you are pregnant or breastfeeding[1]. 

Can lifestyle changes help with psoriasis? 
Yes, avoiding skin injuries, stress, and sunburn can support treatment outcomes[1]. 

What should I do if my psoriasis returns? 
You can restart treatment under the advice of your doctor[1]. 

For the official NHS guide to calcipotriol, visit their website.