Benzydamine

What is benzydamine?

Benzydamine is a non-steroidal anti-inflammatory drug (NSAID) that provides local relief from pain and inflammation in the mouth and throat. It is most commonly sold under the brand name Difflam and is available as a mouthwash, lozenge, or spray which you can buy in shops and pharmacies. Because it acts directly at the site of discomfort and has minimal absorption into the body, it is suitable for short-term, targeted symptom relief[1]. 

What is benzydamine used to treat?

Benzydamine is used to relieve irritation, pain, or swelling in the mouth and throat caused by[1]: 

• Sore throats 

• Mouth ulcers 

• Teething pain 

• Dental procedures 

• Radiation therapy affecting the mouth or throat 

How does benzydamine work?

Benzydamine works by reducing inflammation and numbing the area where it is applied. It does this by acting on the local tissues to[1]: 

• Lower the production of substances that cause swelling and pain 

• Provide a soothing effect by slightly numbing the irritated area 

Who can take benzydamine?

Benzydamine is generally suitable for[1]: 

• Adults 

• Teenagers aged 13 and over: for the mouthwash, lozenges, or spray 

• Children aged 6 to 12: for spray or lozenges 

• Children aged 1 month to 5 years old: spray only 

You should speak to your doctor first if you[1]: 

• Are allergic to benzydamine or other ingredients in the product 

• Have ever had an allergic reaction to NSAIDs like aspirin or ibuprofen 

• Have ever had asthma 

• Are pregnant, trying to get pregnant, or breastfeeding 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

What is the typical dosage of benzydamine?

The dose depends on the formulation used[1]: 

• Mouthwash: Use 15ml every 1.5 to 3 hours. Gargle or rinse for about 30 seconds, then spit out. The solution may be diluted if it causes stinging. 

• Spray: Adults typically use 4 to 8 sprays every 1.5 to 3 hours. Doses for children vary by age – check the label or ask a pharmacist. 

• Lozenges: Suck one lozenge slowly every 1.5 to 3 hours as needed. 

Do not use benzydamine for more than 7 days unless told otherwise by a doctor, pharmacist or dentist. 

How do you take benzydamine?

Use benzydamine exactly as directed for your chosen product[1]: 

• For mouthwash, measure the correct dose using the cap, gargle thoroughly, then spit it out. 

• For spray, aim the nozzle at the painful area and apply the correct number of sprays. 

• For lozenges, allow them to dissolve slowly in your mouth – do not chew or swallow whole. 

Can you stop taking benzydamine?

Yes. You can stop using benzydamine as soon as your symptoms improve. It is not meant for continuous or long-term use[1]. 

What do you do if you take too much benzydamine?

Although overdose is rare with local treatments, using too much could cause unwanted side effects such as[1]: 

• Nausea or vomiting 

• Dizziness 

• Dry mouth or unusual taste 

If you accidentally swallow a large amount or use it excessively, contact your doctor or NHS 111. 

What do you do if you forget to take benzydamine?

If you forget to use benzydamine[1]: 

• Use it as soon as you remember, if needed 

• If it's nearly time for your next dose, skip the missed one 

• Never use more than the recommended amount to make up for a missed dose 

How do you store benzydamine?

Benzydamine should be[1]: 

• Stored in a cool, dry place, away from heat or direct sunlight 

• Kept in its original container 

• Stored out of reach of children 

• Not frozen (especially important for sprays and mouthwash)  

What medicines can’t you take with benzydamine?

Because benzydamine works locally, it generally has a low risk of interacting with other medications. However, caution may be needed if you are taking[1]: 

• Other NSAIDs (e.g., ibuprofen) 

• Medicines that irritate the stomach 

• Herbal supplements or alternative remedies 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of benzydamine?

Most people do not experience side effects, but possible mild side effects include[1]: 

• Mouth or throat irritation 

• Numbness or tingling 

• Dry mouth 

You should contact your GP if you experience any of these symptoms persistently. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

 If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about benzydamine

How quickly does it work? 
It usually begins to relieve pain within a few minutes[1]. 

Can I use benzydamine for a sore throat? 
Yes, that is one of its main uses[1]. 

Is benzydamine an antibiotic? 
No, it is an anti-inflammatory pain reliever[1]. 

Can children use it? 
Yes, but mouthwash is only for those aged 13 and over. Doses for younger children depend on the product – ask a pharmacist[1]. 

Can I eat or drink after using it? 
Wait at least 15 minutes before eating or drinking[1]. 

Can I use it with paracetamol or ibuprofen? 
Yes but speak to your pharmacist if unsure[1]. 

Can I use it during pregnancy or breastfeeding? 
Only if advised by your doctor[1]. 

For the official NHS guide to benzydamine, visit their website.