Aspirin for Pain Relief

What is aspirin for pain relief?

Aspirin (acetylsalicylic acid) is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain, reduce inflammation, and bring down fever. Lower doses are used to help thin the blood. It’s available in different forms, including standard and dispersible tablets (Anadin), suppositories, and a similar medication in gels (Bonjela)[1]. 

What is aspirin used for?

Aspirin is commonly used to manage pain and inflammation associated with various conditions. These include[1]: 

• Headaches and migraines 

• Toothache 

• Period pain 

• Sore throat 

• Neuralgia 

• Muscle aches 

• Sprains and strains 

• Rheumatic pain 

• Sciatica 

• Lumbago 

• Joint swelling and stiffness 

• Fever and flu-like symptoms  

• Thinning blood in certain circumstances 

How does aspirin work?

Aspirin works by blocking the action of enzymes (COX-1 and COX-2) involved in the production of prostaglandins – substances responsible for pain, inflammation, and fever in the body[1]. 

Who can take aspirin?

Aspirin is suitable for most adults and young people over 16, unless otherwise directed by a healthcare provider. You should avoid aspirin if you[1]: 

• Are allergic to aspirin or other NSAIDs 

• Have or have had stomach ulcers or gastrointestinal bleeding 

• Are pregnant, trying to get pregnant, or breastfeeding 

• Have gout, asthma, heavy periods, indigestion or recently had a stroke 

• Have blood clotting, liver, lung, or kidney problems 

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

How do you take aspirin?

Different forms of aspirin are taken in different ways. The following guidance applies[1]: 

• Standard tablets: Swallow with water 

• Dispersible tablets: Dissolve in water before use 

• Suppositories: Insert into the rectum as directed 

• Topical gel (e.g. Bonjela): Apply to mouth ulcers or sores (adults only) 

• It’s important to always take aspirin with food to reduce stomach irritation 

• Always consult product literature for full instructions 

What is the typical dosage of aspirin?

Aspirin usually comes as 300mg tablets. The usual dose depends on the condition being treated. For general pain relief[1]: 

• Adults and over-16s: up to three tablets (900mg) every 4 to 6 hours 

• Maximum dose: 4 doses in 24 hours (total of 3600mg) 

• Older adults may need a lower dose 

If you're using aspirin suppositories: 

• 150mg – the usual dose is 3 to 4 suppositories, 450mg to 600mg, every 4 hours. The maximum dose is 24 of the 150mg suppositories in 24 hours 

• 300mg – the usual dose is 1 to 3 suppositories, 300mg to 900mg, every 4 hours. The maximum dose is 12 of the 300mg suppositories in 24 hours 

Can you stop taking aspirin?

Yes. If you’re using aspirin for short-term pain or fever, you can stop once symptoms go away. If taking aspirin long-term for heart protection, do not stop without medical advice[1].  

What do you do if you take too much aspirin?

Taking too much aspirin can be serious. Seek urgent medical help if overdose is suspected. Signs of overdose may include[1]: 

• Nausea and vomiting 

• Ringing in the ears 

• Dizziness or confusion 

• Breathing problems 

• Seizures or unconsciousness in severe cases 

What do you do if you forget to take aspirin?

If you miss a dose and still need pain relief, take it when you remember. Then leave 4 to 6 hours before taking the next dose. Do not take a double dose to make up for the missed one[1]. 

How do you store aspirin?

Proper storage helps keep the medicine safe and effective[1]. 

• Store below 25°C 

• Keep in the original packaging to protect from light and moisture 

• Keep out of reach of children 

• Do not use after the expiry date [3][4] 

What medicines can’t you take with aspirin?

Some medicines may interact with aspirin increasing the risk of side effects and should be avoided or used with caution. Check with a doctor or pharmacist before combining aspirin with: 

• Other NSAIDs (e.g. ibuprofen) 

• Blood thinners like warfarin, clopidogrel, apixaban, edoxaban, dabigatran, and rivaroxaban 

• Methotrexate 

• Diuretics and ACE inhibitors 

• Corticosteroids 

• SSRIs (antidepressants) 

• High blood pressure medication like furosemide and ramipril 

• Digoxin 

• Lithium 

• Glaucoma medication 

• Diabetes medication 

• Antacids, which can interfere with absorption 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of aspirin?

Most people tolerate aspirin well, but it can cause side effects. 

Common side effects include[1]: 

• Nausea and vomiting 

• Stomach upset or pain 

• Mild indigestion 

• Bleeding more easily than normal 

More serious side effects require urgent medical attention[1]: 

• Vomiting or coughing blood or passing black stools 

• Painful joints as signs of high uric acid levels in blood 

• Liver or kidney problems 

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2]. 

Frequently asked questions about aspirin

Can I take aspirin on an empty stomach? 
No – take it with or just after food to prevent stomach irritation[1]. 

Is aspirin safe during pregnancy? 
Aspirin should not be used during pregnancy unless advised by a healthcare professional.[1]. 

Can children take aspirin? 
Only if specifically prescribed. Never give to under-16s due to the risk of Reye’s syndrome[1]. 

How quickly does aspirin work? 
Usually within 20-30 minutes[1]. 

Can I take aspirin with paracetamol? 
Yes but avoid taking it with other NSAIDs like ibuprofen[1]. 

Is aspirin addictive? 
No – it is not habit-forming[1]. 

Can I drink alcohol while taking it? 
Limit alcohol – excessive drinking increases the risk of stomach bleeding[1]. 

Can aspirin cause ulcers? 
Yes – especially with prolonged use or high doses[1]. 

Is it suitable for long-term use? 
Only under supervision, for conditions like heart disease[1]. 

For the official NHS guide to aspirin, visit their website.