Alogliptin

What is alogliptin?

Alogliptin is a prescription-only medicine used to treat type 2 diabetes. It belongs to a class of drugs called DPP-4 inhibitors (dipeptidylpeptidase-4 inhibitors), also known as gliptins. The brand name is Vipidia, and it is also available in combination with metformin as Vipdomet[1]. 

What is alogliptin used for?

Alogliptin is used to lower blood sugar levels in adults with type 2 diabetes mellitus, particularly when lifestyle changes alone are not enough. It may be used[1]: 

• On its own (monotherapy) if metformin is not suitable 

• In combination with other diabetes medicines like metformin, sulphonylureas, SGLT2 inhibitors, or insulin 

How does alogliptin work?

Alogliptin helps regulate blood sugar by[1]: 

• Increasing insulin production after meals 

• Reducing levels of glucagon, a hormone that raises blood sugar and increases hunger 

• Blocking the DPP-4 enzyme, which normally breaks down incretin hormones that support blood sugar control  

Please tell your doctor or pharmacist about any conditions you may have or medication you take before you start treatment, and always follow the instructions in the Patient Information Leaflet[2].  

Who can take alogliptin?

Most adults aged 18 years and older can take alogliptin. You should speak to a doctor first if you[1]: 

• Have type 1 diabetes 

• Have diabetic ketoacidosis 

• Are taking another antidiabetic medicine that may cause hypoglycaemia  

• Have liver or kidney disease 

• Are a heavy drinker or dependent on alcohol 

• Are pregnant or breastfeeding, or trying to get pregnant 

• Have heart failure or a history of pancreatitis 

• Are allergic to alogliptin or its ingredients 

What is the typical dosage of alogliptin?

The usual dose for adults is[1]: 

• 25mg once daily 

• Lower doses (12.5mg or 6.25mg) may be prescribed for people with reduced kidney function 

How do you take alogliptin?

Alogliptin is taken by mouth[1]: 

• Once daily, ideally at the same time each day 

• Can be taken with or without food 

• Swallow the tablet whole with water 

Can you stop taking alogliptin?

Do not stop taking alogliptin without speaking to your doctor or pharmacist. It is usually taken long-term to manage blood sugar. If it becomes less effective, your treatment may be adjusted[1]. 

What do you do if you take too much alogliptin?

An overdose may cause dizziness, nausea or vomiting, stomach pain. Contact NHS 111 or seek emergency medical help straight away. 

What do you do if you forget to take alogliptin?

If you forget a dose[1]: 

• Take it as soon as you remember 

• If it’s nearly time for your next dose, skip the missed dose 

• Do not take two doses at once  

How do you store alogliptin?

Keep alogliptin in its original container at room temperature – try and avoid moist or humid rooms such as the bathroom. Make sure you keep it out of the reach of children[1]. 

What medicines can’t you take with alogliptin?

Alogliptin can interact with certain medications. Caution is needed when taking[1]: 

• Insulin or sulphonylureas – may increase risk of low blood sugar 

• Other diabetes medicines – doses may need to be adjusted 

Always inform your doctor or pharmacist about all medications and supplements you take before you start a new medicine, and follow the instructions in the Patient Information Leaflet[2]. 

What are the side effects of alogliptin?

Common side effects may include[1]: 

• Headache 

• Low blood sugar 

• Cold-like symptoms (e.g. runny nose, sore throat) 

• Indigestion 

Less common but serious effects include[1]: 

• Pancreatitis (severe stomach pain) 

• Allergic reactions (rash, swelling, difficulty breathing) 

• Bullous pemphigoid (a rare blistering skin condition)  

You should contact your GP if you experience any of these symptoms. In rare cases, the medicine may cause a serious allergic reaction (anaphylaxis). You should call 999 or visit A&E immediately if you believe this is happening[1]. 

Symptoms of anaphylaxis include[1]:  

• Difficulty breathing  

• Tightness in throat and chest  

• Swelling of the tongue or throat  

• Feeling faint or dizzy  

• Blue/grey skin or lips  

• Loss of consciousness 
   

If you experience any side effects, including those not listed, you are encouraged to report them via the Yellow Card Scheme or contact your doctor, pharmacist, or nurse. This information is intended as a summary for general awareness and does not replace professional medical advice. 

The information provided in the side effects section is not a comprehensive list of all possible side effects associated with this medication. For a complete list of side effects, please refer to the Patient Information Leaflet (PIL) provided with your medication or consult your healthcare professional[2].  

Frequently asked questions about alogliptin

How long does alogliptin take to work? 
It starts working within a few days, but the full effect may take a few weeks[1]. 

Does alogliptin cause low blood sugar? 
Not usually when taken alone, but the risk increases when used with insulin or sulphonylureas[1]. 

Can I drink alcohol with alogliptin? 
Limit alcohol as it may affect blood sugar control[1]. 

Can I take alogliptin before surgery? 
Inform your surgeon, doctor or pharmacist – you may need to stop temporarily[1]. 

Are there alternatives to alogliptin? 
Yes – other DPP-4 inhibitors such as sitagliptin and linagliptin may be used instead[1]. 

For the official NHS guide for alogliptin, visit their website.