What is MUSE?

MUSE (alprostadil) is a prescription-only treatment for erectile dysfunction and comes in the form of individual applicators that contain a pellet of alprostadil.

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What are the key benefits of MUSE?

MUSE is an alternative treatment for men who cannot tolerate the side effects of tablets, who cannot take them for medical reasons, or who have failed to achieve satisfactory results with tablet treatments (PDE5 inhibitors).

How does MUSE work?

The active ingredient of MUSE (alprostadil) has a direct effect on the erectile tissue of the penis, causing the blood vessels to dilate and cause an erection. It takes five to 10 minutes to work and normally lasts for 30–60 minutes after administration, but the duration of the treatment will vary from patient to patient.

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How to use MUSE (alprostadil)?

MUSE (alprostadil) should only be used if prescribed by a registered doctor. It's important to read the patient information leaflet supplied with the medicines carefully before using MUSE.

The recommended starting dose is a single applicator of MUSE that will provide 500 mcg of the active ingredient. You should not use more than two doses in 24 hours or more than seven doses a week and you should use MUSE five to 10 minutes before attempting intercourse. The applicator is carefully inserted, as instructed in the enclosed leaflet, into the opening of the penis and the pellet deposited inside the urethra.

Is MUSE suitable for me?

MUSE should not be used at the same time as other medicines to treat erectile dysfunction, and may have less of an effect when taken in combination with treatments for high blood pressure, decongestants and appetite suppressants. If you are taking drugs to prevent blood clots, do not take MUSE as there may be an increased risk for bleeding. In combination with high blood pressure medication, MUSE use may increase symptoms of dizziness and fainting.

If you have heart problems, have suffered a recent stroke or have been told not to have sex for health reasons, do not use MUSE. If you have a history of long lasting erections (more than 4 hours), a condition that might result in a long-lasting erections or another illness including sickle cell anaemia or trait, thrombocythemia, polycythemia, multiple myeloma, or leukaemia, then MUSE is unsuitable.

Do not use MUSE if you have an abnormally formed penis, if you have an inflammation or infection of the penis or urethra or if you are prone to a venous thrombosis.

MUSE may make you feel dizzy or faint. Do not drive or operate machinery if you feel dizzy or faint.

MUSE should not be used if your female partner is or may be pregnant, unless you use a condom barrier. Please ask your doctor or pharmacist for advice before using MUSE if your partner is breast feeding.

MUSE will not protect you or your partner from any sexually transmitted diseases. If you have a blood born disease the use of MUSE could result in the spread of the disease to your partner.

What are the side effects of MUSE?

MUSE can cause side effects - although not everybody gets them.

If you experience any of the following symptoms, contact your doctor immediately:

  • You have a long lasting erection of more than four hours
  • Your penis becomes scarred, bent or kinked
  • Your testes or scrotum become red, swollen or painful, or develop lumps called spermatocele, which are cysts containing sperm

Very common side effects (affects more than 1 in 10 patients):

  • Burning feeling in the urethra
  • Painful penis

Common possible side effects (affects less than 1 in 10 patients):

  • Headache
  • Dizziness
  • Muscle spasms
  • Low blood pressure
  • Minor bleeding in the urethra
  • Pain in the testes
  • Burning or itching in partner’s vagina
  • Bruised penis
  • Increased erection
  • Peyronie’s disease (condition resulting in pain and abnormal curvature, shortening or narrowing of the penis)

For a full list of potential side effects and other important information, please read the patient leaflet provided in the pack before starting any course of treatment. The leaflet can also be viewed online here.

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