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Zantac 75 contains the active ingredient ranitidine. Ranitidine acts in the stomach to decrease the production of stomach acid. Zantac tablets work by blocking the histamine receptors found on the cells in the stomach lining. Stomach acid is produced normally during the digestive process however on some occasions excess stomach acid is produced and backs up the food pipe and causes pain and a burning sensation. Zantac also provides all day or all night relief.