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What is Premique?
Premique tablets contain two active ingredients:
- Conjugated oestrogens 625mcg per tablet
- Medroxyprogesterone acetate 5mg per tablet.
Conjugated oestrogens replace the oestrogen naturally found in the body, and work to help menopausal symptoms. Medroxyprogesterone is a synthetic form of progesterone (a “progestogen” hormone) and this protects the lining of the uterus.
Premique tablets should only be taken by women who have not had a hysterectomy (those who have a uterus). For women who do not have a uterus, a different form of hormone replacement therapy (HRT) will be recommended – one, like Premarin, that doesn’t contain a progestogen.
Premique tablets are prescribed to women who have been through the menopause. They work to replace the oestrogen that is no longer being produced. This helps to relieve the symptoms of the menopause, and restores the protective effect oestrogen has against the risk of cardiovascular disease. Premique is a HRT product for which you do not have a monthly bleed.
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How to take Premique
Before using Premique tablets, it’s important you read the enclosed leaflet carefully.
The doctor would usually consider the Premique tablets, rather than the Premique Low Dose tablets, to start with for most women.
The dose is one tablet to be taken every day, at roughly the same time, before or after food. The tablets are to be taken continuously without a break between packs.
Is Premique suitable for me?
In certain situations Premique, like all medicines, should be used with caution or would not be prescribed at all. This could be the case for women over 65, or women with cancer or a history of cancer. Undiagnosed genital bleeding, liver or kidney problems, untreated endometrial hyperplasia (excessive growth of tissue in the womb) or current or previous venous thromboembolism (deep vein thrombosis, or pulmonary embolism) would also need to be considered by the doctor. Plus, disorders of blood clotting, current or previous circulation problems including heart disease, angina, or a heart attack, or porphyria may mean Premique isn’t recommended. Finally, people who are allergic to any of the active or inactive ingredients will also be advised against this treatment.
Additionally, you must mention to the online doctor if you have now, or have had in the past, any of these conditions: endometriosis or risk factors for thromboembolic disorders (that might be major surgery, prolonged immobilisation, obesity, cancer, smoking or excessive drinking). You’ll also need to make it clear if you have now, or have previously had, risk factors for oestrogen dependent tumours (for example first-degree heredity for breast cancer), hypertension, liver or kidney problems or diabetes mellitus with or without vascular involvement. Cholelithiasis, migraine or (severe) headache, systemic lupus erythematosus (SLE), a history of endometrial hyperplasia, epilepsy, asthma, or otosclerosis will also need to be discussed with the doctor and Premique may be advised against.
During your consultation, please tell the doctor if you are taking any other medicines, either prescribed or bought. Premique tablets can cause problems if they’re taken alongside certain medications. This includes some medicines for epilepsy, some medicines for infections (for example rifampicin, rifabutin, nevirapine, efavirenz), and some medicines for HIV/AIDS. Please also let us know if you’re taking warfarin and other anticoagulants, and St John's Wort.
During the consultation, the doctor will need to made fully aware of all the details of your general health to they can be sure Premique tablets are suitable for you.
What are the side effect of Premique?
You’ll need to be aware that while you may not experience them, Premique can cause side effects.
Some side effects have the potential to be serious. Should you experience any of the following, stop using Premique and tell your local doctor immediately:
- Breakthrough bleeding (unexpected vaginal bleeding or spotting)
- Painful menstrual periods
- Painful swelling and a redness of the legs
- Chest pain that comes on suddenly
- Difficulty in breathing
- Chest pain that moves to your arm or neck
- Yellowing of the eyes and face (which is also known as jaundice)
- Sharp increase in your blood pressure
- Migraine-like headaches that cannot be explained
- Breast changes (this can be anything from dimpling of the breast skin, to changes in the nipple, and visible lumps)
There are other side effects that have been reported including breast pain, vaginal discharge, headache and dizziness. There’s also the potential for you to experience an increased libido, depression, an increase in blood pressure, palpitations, fluid retention, nose bleeds, indigestion and other types of stomach discomfort. Itching, skin rashes, hair loss, weight gain, sweating, and feeling faint after eating may also be experienced.
HRT is known to increase the risk of conditions including thrombosis, stroke, breast cancer, and ovarian cancer. Oestrogen-only HRT has an increased risk of endometrial cancer, but the medroxyprogesterone in Premique will help protect you from this extra risk. Please be aware that there is also an increased chance of contracting heart disease in women who begin a course of HRT more than 10 years after the onset of the menopause. Because of these reasons, it’s advised that the minimum effective dose of HRT should be used, and only for the shortest length of time.
The full list of potential side effects and any other important information you need to be aware of is available on the patient information leaflet provided in the pack. The leaflets can also be viewed online here: