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Premarin (conjugated oestrogens, equine)

What are Premarin tablets?

Premarin tablets contain conjugated oestrogens, in a strength of either 300mcg (0.3mg), 625mcg (0.625mg), or 1.25mg per tablet.

Conjugated oestrogens replace the oestrogen that is found naturally in the body. Premarin tablets are a form of hormone replacement therapy (HRT), and are prescribed to women once they’ve been through the menopause. The treatment replaces the oestrogen that is no longer being produced. This works to relieve the symptoms of the menopause and ensures the protective effect oestrogen has against the risk of cardiovascular disease is restored.

Premarin is only intended for women who have had a hysterectomy. However, if women who still have a uterus (womb) wish to try HRT, a form that also contains a progestogen should be used, to prevent overgrowth of tissue in the uterus and complications that can develop because of that.

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Premarin 300mg Tablets Premarin 300micrograms Tablets £0.09 per tablet Prescription only Start consultation
Premarin 625micrograms Tablet Premarin 625micrograms Tablets £0.06 per tablet Prescription only Start consultation
Premarin 1.25mg Tablets Premarin 1.25mg Tablets £0.05 per tablet Prescription only Start consultation

How to take Premarin tablets

Please ensure you read the enclosed leaflet carefully before using Premarin.

You should take one tablet, once a day. This can be before or after food, whatever suits you best, but try to keep to the same time each day. You should start on the lowest 300mcg strength of tablets, only moving up to a higher strength if your menopausal symptoms are not well controlled.

Premarin is taken every day (unlike some oral contraceptives which allow for a seven-day break).

Are Premarin tablets suitable for me?

In various situations, Premarin, like all medicines, should be used with caution or would not be recommended. This might be the case, for example, in women over the age of 65, or women with known or suspected breast cancer (even if you’ve now fully recovered). It will also apply to those women with known or suspected oestrogen dependent malignant tumours (for example endometrial cancer); undiagnosed genital bleeding and untreated endometrial hyperplasia. You’ll also need to make the online doctor aware if you’ve previously had or currently have venous thromboembolism (including deep vein thrombosis or pulmonary embolism); known thrombophilic disorders; currently or previously had angina or ever had a heart attack; liver or kidney problems or porphyria. People who are allergic to any of the active or inactive ingredients will also be advised against using this treatment.

You will need to mention to the doctor if you have now, or have previously had, any of the following conditions: endometriosis, any risk factors that could imply thromboembolic disorders (including major surgery, prolonged immobilisation, obesity, cancer, smoking and excessive drinking). Please also make us aware if you have now, or have had in the past, any risk factors for oestrogen dependent tumours (including first-degree heredity for breast cancer), hypertension, liver or kidney problems (including liver adenoma) and diabetes mellitus with or without vascular involvement. Cholelithiasis, migraine or (severe) headache, systemic lupus erythematosus (SLE) and a history of endometrial hyperplasia, epilepsy, asthma, or otosclerosis will also need to be discussed with the doctor.

Be sure to tell the doctor about any other medicines you’re taking, whether prescribed by your doctor or bought over the counter. We need to know because Premarin can cause problems if it’s taken with certain other medicines. These include some medicines for epilepsy, others for infections (for example rifampicin, rifabutin, nevirapine and efavirenz), and some for HIV/AIDS treatments. You’ll also need to let us know if you’re taking warfarin and other anticoagulants, or St John's Wort, which is a herbal preparation.

You should give as many details as possible about your general health in the consultation. This is so the doctor has all the information required to assess the suitability of Premarin tablets for you.

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What are the side effects of Premarin tablets?

If you’re considering Premarin, you should be aware that, like all medicines, it can cause side effects, although not everybody will experience them.

Some of these side effects can be potentially serious. Stop taking Premarin and tell your local doctor immediately if you experience any of the following:

  • Unexpected vaginal bleeding or spotting (breakthrough bleeding)
  • Periods that become extremely painful
  • Swelling that becomes painful and redness of the legs
  • Sudden and unexpected chest pain
  • Breathing difficulties
  • Pain in your chest that spreads to your arm or neck
  • Yellowing of the eyes and face (known as jaundice)
  • A quick increase in your blood pressure
  • Unexplained migraine-like headaches
  • Any noticeable breast changes. This can include dimpling of the breast skin, differences in the nipple, or any lumps that you can see or feel.

This list isn’t exhaustive, however. There are other more serious side effects that have been reported including breast pain and, in some severe cases, breast cancer.

You may also experience vaginal discharge, headache, dizziness, increased libido, depression, increased blood pressure, palpitations, fluid retention, nose bleeds, indigestion and other type of stomach discomfort. There’s also the possibility of itching, skin rashes, hair loss, weight gain, sweating, and a faint feeling following mealtimes.

HRT is also likely to increase the risk of thrombosis, stroke, endometrial cancer and ovarian cancer. You should also be aware that there is an increased risk of heart disease in women who start the treatment more than 10 years after the beginning of the menopause. This is why the minimum effective dose of HRT should be used – and only for the shortest length of time.

You can find a full list of potential side effects and any other information you need to be aware of in the patient information leaflet provided in the pack. You should always read this leaflet before starting treatment – it can also be viewed online here.

Online consultations are available through the Pharmacy2U Online Doctor service which could lead to prescription-strength treatments being arranged for you.

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