Spedra (Avanafil) prescription tablets to treat erectile dysfunction

What is Spedra?

Spedra is also known under its generic name avanafil, it is a prescription-only treatment for erectile dysfunction, launched in the UK in March 2014.

Spedra is classed as a "PDE5 inhibitor". It comes as a pale yellow, oval tablet available in three strengths - Spedra 50mg, 100mg and 200mg in packets of four or eight tablets.

The Pharmacy2U Online Doctor Service offers a convenient and confidential consultation service for Spedra.

Start an online consultation with one of our UK-registered GPs
Our GP may advise, prescribe or recommend further tests
Receive certified genuine medication by your chosen delivery method
Start questionnaire

What are the key benefits of Spedra?

Spedra has been shown to be effective in clinical trials involving over 1000 men. It was tested on all types of men with erectile dysfunction including men with erectile dysfunction caused by type 1 and type 2 diabetes and in men with erectile dysfunction following bilateral nerve-sparing radical prostatectomy. Spedra was shown to be successful for all types of men at all strengths.

Of those men with ED, the mean percentage of attempts resulting in successful intercourse was approximately 47%, 58%, and 59% for the 50 mg, 100 mg, and 200 mg avanafil groups, respectively, compared to approximately 28% for placebo (a treatment with no active ingredient).

In men with type 1 or type 2 diabetes, the mean percentage of attempts resulting in successful intercourse was approximately 34% and 40% for the 100 mg and 200 mg avanafil groups, respectively, compared to approximately 21% for placebo. In men with ED following bilateral nerve-sparing radical prostatectomy, the mean percentage of attempts resulting in successful intercourse was approximately 23% and 26% for the 100 mg and 200 mg avanafil groups, respectively, compared to approximately 9% for placebo.

How does Spedra work?

Spedra works by relaxing the blood vessels to the penis, allowing better blood flow. It takes between 15 to 30 minutes to work. It's effectiveness is not normally affected by eating or drinking alcohol before taking the treatment. Sexual stimulation is needed for Spedra to be effective.

Start questionnaire

How to take Spedra (avanafil)?

The recommended dose is a 100 mg tablet, taken when you need it. You should not take it more than once a day.

Tell your doctor if you think your dose is too strong or too weak. They may suggest you switch to a different dose of this medicine. Dose adjustments can also be required if Spedra is used together with certain other medicines. If you are taking a medicine such as erythromycin, amprenavir, aprepitant, diltiazem, fluconazole, fosamprenavir or verapamil (‘moderate CYP3A4 inhibitors’) the recommended dose of Spedra is a 100 mg tablet, with an interval of at least two days between doses.

You should take Spedra about 30 minutes before you have sexual intercourse.

Grapefruit juice can increase exposure to the medicine and should be avoided within 24 hours prior to taking Spedra. Drinking alcohol at the same time as taking Spedra may increase your heart rate and lower your blood pressure. You may feel dizzy (especially when standing), have a headache or feel your heart beating in your chest (palpitations). Drinking alcohol may also decrease your ability to get an erection.

Is Spedra suitable for me?

It's important to read the enclosed leaflet carefully before using any medication.

Spedra should only be taken if prescribed by a registered doctor. It can be dangerous if you take it at the same time as other medicines including some that are used to treat chest pain (angina), as well as with some recreational drugs includingalkyl nitrites (poppers). There are other medicines that can interact with Spedra and you should tell the doctor about all the medicines you are taking so these can be taken into consideration.

Spedra is unsuitable for men with cardiac disease of a severity where sex is inadvisable, unstable angina or angina occurring during sexual intercourse, low or high blood pressure or men who have had a recent stroke, heart attack or life threatening irregular heart beat in the last 6 months. Spedra is unsuitable for men with severe liver or kidney problems. Patients with known eye problems including Patients loss of vision in one eye because of non-arteritic anterior ischemic optic neuropathy (NAION), regardless of whether this episode was in connection or not with previous type 5 phosphodiesterase (PDE5) inhibitor exposure and patients with known hereditary degenerative retinal disorders should not take Spedra.

What are the side effects of Spedra?

Spedra can cause side effects, although not everybody gets them. Side effects that are considered to be common (experienced by between 1% and 10% of men) include headaches, facial flushing and nasal congestion.

For a full list of potential side effects and other important information, please read the patient leaflet provided in the pack before starting any course of treatment. The leaflet can also be viewed online here.

Start questionnaire

Spedra not working? Why not try one of these?

Cialis Tadalafil
Levitra Vardenafil
Viagra Sildenafil

Why choose Pharmacy2U

  • UK Registered GPs
  • Choose your preferred treatment
  • Regulated by the Care Quality Commission
Start questionnaire

Online GP Consultations in 3 straightforward steps