Bupropion: What Is It and How Can It Support Weight Loss

How bupropion can cause weight loss

The exact reason why bupropion can cause weight loss is not fully understood, but it may be related to its effects on dopamine and norepinephrine levels in the brain. These chemicals play a role in appetite regulation, and bupropion may help to reduce cravings and increase feelings of fullness.

A 2016 study suggests that the medication's noradrenaline, dopamine and serotonin-stimulating effects could boost energy and mood, encouraging less emotional eating and giving users more energy to exercise and engage in other weight loss-supporting activities. It’s because of these satisfaction and mood-boosting properties that bupropion has also been used for support with Seasonal Affective Disorder (SAD) and ADHD (attention deficit hyperactivity disorder) as well as as a tool to help with nicotine addiction. 

Efficacy of naltrexone and bupropion for weight loss

Studies on the effectiveness of bupropion for weight loss have shown mixed results. Some studies have found that it can lead to modest weight loss, while others have found no significant effect.  Bupropion is typically only prescribed for weight loss when combined with naltrexone ( another medication used to treat addictions) and other weight loss measures, such as diet and exercise.

Naltrexone/bupropion (Mysimba) is a combination medication that is NICE (National Institute for Health and Care Excellence) approved for weight loss. It works by affecting the brain's reward system, reducing cravings and helping you feel full sooner. Naltrexone blocks the pleasure response associated with eating, while bupropion helps regulate mood and energy levels.

You can find more information on how naltrexone and bupropion, available under the brand Mysimba, works for weight loss in our Mysimba guide. 

Risks and dangers of using bupropion for weight loss

Bupropion can cause side effects such as but not limited to dry mouth, headache, nausea, and insomnia. In some cases, it can also lead to more serious side effects, such as seizures or mental health problems.

Importance of consulting a doctor

If you are interested in the weight loss potential of naltrexone and bupropion, it is important to talk to a licensed medical professional. There are strict prescription criteria for all weight loss medications. While you can get some medicines such as orlistat in lower doses over the counter in some pharmacies, other medications including Mysimba require a comprehensive consultation. This consultation will determine if your circumstances are suitable for the prescription of a weight loss aide. 

You can start an online consultation with Pharmacy2U; you will be asked for information including your body weight, height, exercise and lifestyle habits, as well as for images of yourself to confirm your identity and body weight. 

This information will be reviewed by one of our licensed medical professionals who will recommend a course of action, which might include a prescription for a weight loss medication. 

They will determine which weight loss medication is a safe and appropriate option for you and we will communicate all decisions and if applicable any prescriptions issued to you by your GP.