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SECTION_START: Description Mysimba is a weight loss drug that supresses appetite, promoting a feeling of fullness with less food intake. It's taken daily, and noticeable effects typically appear within weeks. For optimal results, combine Mysimba with a balanced diet and exercise regimen.
SECTION_END: Description
SECTION_START: Directions Take tablets with a meal, swallowing them with water. The dosage is personalised by your doctor upon receiving the medication.
Typically, treatment begins with one tablet in the morning, gradually increasing to two tablets twice daily after four weeks.
If you forget a Mysimba dose, avoid doubling up. Simply skip the missed dose and resume your regular medication schedule.
SECTION_END: Direction
SECTION_START: Warnings Like all medicines, this medicine can cause side effects, although not everybody gets them.
Serious side effects Tell your doctor straight away if you notice any of the following serious side effects: &bull;&nbsp;&nbsp;&nbsp;&nbsp;Suicidal thoughts and feeling depressed. The frequency of the side effects of suicide attempts, suicidal behaviour, suicidal thoughts and feelings of depression are not known and cannot be estimated from the available data in people taking Mysimba. There have been reports of depression, suicidal thoughts, and suicide attempts during treatment with Mysimba. If you have thoughts about harming yourself or other distressing thoughts, or if you are depressed and notice that you feel worse or develop new symptoms, contact your doctor or go to a hospital straight away. &bull;&nbsp;&nbsp;&nbsp;&nbsp;Fits (seizures) may affect up to 1 in 1,000 people taking Mysimba with a risk of having a fit. Symptoms of a fit include convulsions and usually loss of consciousness. Someone who has had a fit may be confused afterwards and may not remember what has happened. Fits are more likely if you take some other medicines or if you are at a higher-than-usual risk of fits. &bull;&nbsp;&nbsp;&nbsp;&nbsp;Erythema multiforme and Stevens-Johnson Syndrome frequency cannot be estimated from the available data in people taking Mysimba. Erythema multiforme is a severe condition of the skin that may affect the mouth and other parts of the body, with red, often itchy spots starting on the limbs. Stevens-Johnson Syndrome is a rare skin condition with severe blisters and bleeding in the lips, eyes, mouth, nose and genitals. &bull;&nbsp;&nbsp;&nbsp;&nbsp;Acute generalised exanthematous pustulosis frequency cannot be estimated from the available data in people taking Mysimba. A red, scaly, widespread rash with bumps under the skin and blisters accompanied by fever. The symptoms usually appear at the initiation of treatment. &bull;&nbsp;&nbsp;&nbsp;&nbsp;Rhabdomyolysis frequency cannot be estimated from the available data in people taking Mysimba. Rhabdomyolysis is an abnormal breakdown of muscle tissue, which can lead to kidney problems. Symptoms include severe muscle cramps, muscle pain or muscle weakness. &bull;&nbsp;&nbsp;&nbsp;&nbsp;Lupus skin rash or worsening of lupus symptoms frequency cannot be estimated from the available data in people taking Mysimba. Lupus is an immune system disorder affecting the skin and other organs. If you experience lupus flares, skin rash or lesions (particularly in sun-exposed areas) while taking Mysimba, contact your doctor straight away, as it might be necessary to stop the treatment. &bull;&nbsp;&nbsp;&nbsp;&nbsp;Serotonin syndrome, which can manifest as mental status changes (e.g. agitation, hallucinations, coma), and other effects, such as body temperature above 38&deg;C, increase in heart rate, unstable blood pressure, exaggeration of reflexes, muscular rigidity, lack of coordination and/or gastrointestinal symptoms (e.g. nausea, vomiting, diarrhoea), while taking Mysimba together with medicines used for the treatment of depression (such as paroxetine, citalopram, escitalopram, fluoxetine and venlafaxine.) Frequency cannot be estimated from the available data in people taking Mysimba.
Other side effects include: Very common side effects (may affect more than 1 in 10 people): &bull; Feeling sick (nausea), being sick (vomiting) &bull; Constipation &bull; Headache.
Common side effects (may affect up to 1 in 10 people): &bull; Anxiety &bull; Dizziness, feeling of dizziness or &ldquo;spinning&rdquo; (vertigo) &bull; Feeling shaky (tremor) &bull; Difficulty in sleeping (make sure you do not take Mysimba near bedtime) &bull; Changes in the taste of food (dysgeusia), dry mouth &bull; Difficulty concentrating &bull; Feeling of tiredness (fatigue) and sleepiness, drowsiness or lack of energy (lethargy) &bull; Ringing in the ears (tinnitus) &bull; Fast or irregular heartbeat &bull; Hot flush &bull; Increased blood pressure (sometimes severe) &bull; Pain in the upper part of the abdomen &bull; Pain in the abdomen &bull; Excessive sweating (hyperhidrosis) &bull; Rash, itching (pruritus) &bull; Hair loss (alopecia) &bull; Irritability &bull; Feeling jittery.
Uncommon side effects (may affect up to 1 in 100 people): &bull; Hives (urticaria) &bull; Hypersensitivity &bull; Abnormal dreams &bull; Feeling nervous, spacey, tense, agitation, mood swings, tremors of the head or limb, which increases when trying to perform a particular function (intention tremor) &bull; Balance disorder &bull; Loss of memory (amnesia), Tingling or numbness of the hands or feet &bull; Motion sickness &bull; Burping &bull; Abdominal discomfort &bull; Indigestion &bull; Inflammation of the gallbladder (cholecystitis) &bull; Increased creatinine levels in the blood (indicating loss of kidney function) &bull; Increased liver enzymes and bilirubin levels, liver disorders &bull; Difficulty in getting or keeping an erection &bull; Feeling abnormal, weakness (asthenia) &bull; Thirst, feeling hot &bull; Chest pain &bull; Increased appetite, weight gain.
Rare side effects (may affect up to 1 in 1,000 people): &bull; Low amount of certain white blood cells (Lymphocyte count decreased) &bull; Decreased haematocrit (indicating loss of red blood cell volume) &bull; Swelling of eyelids, face, lips, tongue or throat, which can cause great difficulty in breathing (angioedema) &bull; Excessive loss of body water (dehydration) &bull; Hallucinations &bull; Fainting, almost fainting (presyncope), loss of consciousness &bull; Fits &bull; Passage of fresh blood through the anus, usually in or with stool (haematochezia) &bull; Projection of an organ or the tissue encompassing an organ through the wall of the cavity that normally contains it (hernia) &bull; Toothache &bull; Dental caries, cavities &bull; Pain in the lower part of the abdomen &bull; Injury to the liver due to drug toxicity &bull; Jaw pain &bull; A disorder characterised by a sudden compelling urge to urinate (micturition urgency) &bull; Irregular menstrual cycle, vaginal bleeding, dryness of the female vulva and vagina &bull; Coldness of extremities (hands, feet).
Not known side effects (frequency cannot be estimated from the available data): &bull; Swollen glands in the neck, armpit or groin (lymphadenopathy) &bull; Mood disorders &bull; Irrational ideas (delusions) &bull; Psychosis &bull; Feeling of acute and disabling anxiety (panic attack) &bull; Loss of sexual desire &bull; Feeling hostile &bull; Severe suspiciousness (paranoia) &bull; Aggression &bull; Attention disturbance &bull; Nightmares &bull; Confusion, disorientation &bull; Memory impairment &bull; Restlessness &bull; Muscle stiffness, uncontrolled movements, problems with walking or coordination &bull; Blurred vision, eye pain, eye irritation, eye swelling, watery eyes, increased sensitivity to light (photophobia) &bull; Ear pain, ear discomfort &bull; Difficulty in breathing &bull; Nasal discomfort, congestion, runny nose, sneezing, sinus disorder &bull; Sore throat, a disorder of the voice, cough, yawning&nbsp; &bull; Haemorrhoids, ulcer &bull; Diarrhoea &bull; Passing wind (flatulence) &bull; Hepatitis &bull; Acne &bull; Groin pain &bull; Muscle pain &bull; Joint pain&nbsp; &bull; Abnormally frequent urination, painful urination &bull; Chills &bull; Increased energy.
Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed.&nbsp; By reporting side effects, you can help provide more information on the safety of this medicine.
SECTION_END: Warnings
SECTION_START: Ingredients The active substances are naltrexone hydrochloride and bupropion hydrochloride.
Each tablet contains 8 milligrams of naltrexone hydrochloride, equivalent to 7.2 milligrams of naltrexone, and 90 milligrams of bupropion hydrochloride, equivalent to 78 milligrams of bupropion.
The other ingredients (excipients) are: Tablet core: microcrystalline cellulose, hydroxypropyl cellulose, lactose anhydrous, lactose monohydrate, cysteine hydrochloride, crospovidone type A, magnesium stearate, hypromellose, edetate disodium, colloidal silicon dioxide, and indigo carmine aluminium lake (E132).&nbsp; Film-coating: poly(vinyl alcohol), titanium dioxide (E171), macrogol (3350), talc and indigo carmine aluminium lake (E132).
SECTION_END: Ingredients
SECTION_START: FAQ What is Mysimba? Mysimba is a prescription weight loss tablet taken once or twice daily. Unlike other weight loss medications, it suppresses appetite, reducing food intake. This can aid weight loss by making you feel full with less food.
How does Mysimba work? Mysimba contains naltrexone and bupropion, acting on the brain's appetite control. It reduces hunger and curbs snacking habits, helping you eat less between meals.
How long does Mysimba take to work? Mysimba starts working immediately, but the full effects may take weeks. After 16 weeks, expect around 5% weight loss; less may prompt alternative treatments. Consistent results are seen with a balanced diet and regular exercise.
How long does Mysimba last? The effects persist as long as the medication is taken. A 112-tablet pack typically lasts about 5 weeks upon initiation.
How effective is Mysimba? Studies show weight loss averaging 3.7-5.7% with Mysimba. Outcomes vary based on adherence to healthy lifestyle choices.
Who can take Mysimba? Suitable for adults with BMI &ge; 30 or BMI between 27 and 30 with weight-related health risks. Prescription depends on the doctor's evaluation and consideration of individual health factors. SECTION_END: FAQ

MySimba (naltrexone with bupropion)

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