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Evorel (estradiol valerate)

What are Evorel patches?

Used by women after the menopause to replace the oestrogen that is no longer being produced, Evorel patches are a form of hormone replacement therapy (HRT). The treatment is used to relieve the symptoms of the menopause, and helps to restore the protective effect oestrogen has against the risk of cardiovascular disease.

Evorel patches contain the active ingredient estradiol hemihydrate, in a choice of four strengths:

  • Evorel 25 contains 1.6mg estradiol per patch, releasing 25mcg of estradiol in 24 hours.
  • Evorel 50 contains 3.2mg estradiol per patch, releasing 50mcg of estradiol in 24 hours.
  • Evorel 75 contains 4.8mg estradiol per patch, releasing 75mcg of estradiol in 24 hours.
  • Evorel 100 contains 6.4mg estradiol per patch, releasing 100mcg of estradiol in 24 hours.
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Evorel 25 Patches Evorel 25 Patches £0.53 per patch Prescription only Start consultation
Evorel 50 Patches Evorel 50 Patches £0.61 per patch Prescription only Start consultation
Evorel 75 Patches Evorel 75 Patches £0.64 per patch Prescription only Start consultation
Evorel 100 Patches Evorel 100 Patches £0.67 per patch Prescription only Start consultation

How do Evorel patches work?

Estradiol is a synthetic form of the oestrogen that is found naturally in the body and is used to replace the oestrogen which is no longer being produced.

How to use Evorel patches

It's important you read the enclosed leaflet carefully before using Evorel patches.

Apply each Evorel patch twice a week, to an area of clean, dry, healthy skin below the waistline. Place it on a different area of skin each time and make sure you do not to apply the patches on or near the breasts.

You can keep the patch on when you have a shower or bath. If it falls off, wait until the skin is dry and at normal temperature before applying another one. Simply replace it with a new one immediately, if it falls off at any other point. You can use baby oil to remove any glue that is left on the skin after you take a patch off.

You would usually start with the Evorel 50 patches, and the strength of the patches can be adjusted up or down in the future by the doctor depending on how you respond to them.

Are Evorel patches suitable for me?

Evorel patches are only intended for women who have had a hysterectomy. For women who still have a uterus (womb) and are considering this HRT, you will be offered a different form of it that also contains a progestogen, to prevent overgrowth of tissue in the uterus and complications that can develop because of that.

Just like with all medical treatments, Evorel patches may not be suitable for all situations and circumstances. This includes women over 65, or those with cancer or a history of cancer; undiagnosed genital bleeding and either liver or kidney problems. Evorel may not be recommended if you have had untreated endometrial hyperplasia (excessive growth of tissue in the womb); current or previous deep vein thrombosis or pulmonary embolism; or blood clotting disorders. If you currently have or have previously had circulation problems including angina or a heart attack and porphyria, this will need to be discussed; and people who are allergic to the active or inactive ingredients will more than likely have a different medicine prescribed.

In addition, you should make the online doctor aware if you have suffered from any of the following conditions in the past or currently have them – endometriosis, thromboembolic disorders (such as major surgery, prolonged immobilisation, obesity, cancer, smoking and excessive drinking) or the risk factors for oestrogen dependent tumours (first-degree heredity for breast cancer for example). Notify your GP and the Online Doctor about hypertension, problems with your liver or kidney, diabetes mellitus (either with or without vascular involvement), migraines or painful headaches, systemic lupus erythematosus (SLE) and cholelithiasis. And if you have a track record of endometrial hyperplasia, epilepsy, asthma, or otosclerosis, this will also need to be discussed.

It is important to tell the doctor if you are taking any other medicines whilst in your consultation – it doesn’t matter if they are from your doctor or purchased from a pharmacy without a prescription. Evorel patches can cause problems if used at the same time as certain other medicines, including those to treat epilepsy, infections (rifampicin, rifabutin, nevirapine and efavirenz for example), and HIV/AIDS. Please also let us know if you’re taking warfarin and other anticoagulants, or herbal preparations like St John's Wort.

Give a full picture of your general health in the consultation too, so the doctor has all the information required to assess the suitability of Evorel Patches for you.

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What are the side effects of Evorel patches?

Evorel patches can cause side effects – this is common in most treatments but not everybody gets them. The most common side effect is that you may experience a rash or other skin irritation where the patches are applied.

There are some side effects that are potentially serious. If you experience any of the following, you should stop using Evorel patches and tell your local doctor immediately:

  • Vaginal bleeding that is unexpected or spotting (also known as breakthrough bleeding)
  • Menstrual periods which are painful
  • Noticeable redness and painful swelling of the legs
  • Sudden pains in your chest
  • Breathing difficulties
  • Suffering from pains in your chest, spreading through to your arm or neck
  • Jaundice (where your eyes and face turn a tint of yellow)
  • Rapid increase in your blood pressure
  • Unexpected headaches and symptoms of a migraine
  • Changes to your breasts, such as dimpling of the skin, the nipple, as well as lumps that you may be able see or feel.

Other reported side effects include an increase in your blood pressure, the sensation of dizziness, headaches, pain in your breast and the risk of breast cancer, bleeding from the nose, indigestion, discharge from the vagina and signs of depression. You may also experience an increased libido, feelings of faintness after eating, hair loss, weight gain, sweating, itching and skin rashes, fluid retention, palpitation and varying discomfort in your stomach.

HRT can also increase the risk of having a stroke, thrombosis, and endometrial or ovarian cancer. There is also an increased risk of heart disease in women who start HRT more than 10 years after the onset of the menopause – the minimum effective dose of HRT should be used, for the shortest length of time.

Please read the patient information leaflet provided in the pack before starting any Evorel treatment. The leaflets can also be viewed online here:

You can carry out a hormone replacement therapy consultation through our confidential and convenient Online Doctor service, which could lead to Evorel patches being prescribed.

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