Skip to main content

Differin Cream and Gel

What is Differin?

Differin Cream and Gel are preparations that are applied directly to the skin to treat acne. The treatment is very effective at reducing inflammation, and is therefore especially useful where there are blackheads, whiteheads, and/or pustules on the skin. The creams and gels that are applied to the skin in this way are also well-suited for people who cannot take - or do not wish to take - an antibiotic orally.

Start an online consultation with one of our UK-registered GPs
Our GP may advise, prescribe or recommend further tests
Receive certified genuine medication by your chosen delivery method
Start Consultation
Differin Gel Differin (Adapalene) Gel 0.1% £0.45 per gram Prescription only Start consultation

How does Differin work?

Differin works through an active ingredient called adapalene, which functions in a similar way to other acne medicines called 'retinoids' and are derived from vitamin A.

How to use Differin?

Differin preparations are usually applied to the affected area once a day, at night-time, after the area has been washed and rinsed with warm water and patted dry. Both preparations come in a tube, and are applied to the skin with the fingertips. Differin should not be used by children under the age of 12.

It may take a little time before you will see Differin working, but it should not be used for more than 12 weeks (three months) continuously without checking with your doctor that it is still appropriate and is working well.

The cream or gel should be used carefully on the face; avoid contact with the eyes and mouth, the angles of the nose, and any cuts or other patches of sensitive or broken skin. You should not expose yourself to excessive amounts of sunlight and avoid sun lamps while using this product, to avoid skin irritation and dryness.

Is Differin suitable for me?

There are some situations where Differin Cream or Gel should be used with caution or would not be recommended - for example, in patients who have severe acne or acne covering a large area of the body. It is not usually used at the same time as any other treatments for acne. If it doesn't work for you, talk to your doctor as a different acne treatment might be better.

Tell the doctor if you are taking any other medicines, either from your doctor or purchased from a pharmacy. Differin may not be suitable or may need to be used with caution if you are taking other treatments, such as different medicines or creams for acne, especially other ones that contain vitamin A derivatives (such as Isotrex). It will not be suitable if you are allergic to adapalene, or any of the other ingredients.

Differin is best suited for use on dry and fair skin, and can be used on the chest or back as well as on the face, as necessary.

What are the side effects of Differin?

Like all medicines, Differin can cause side effects, although not everybody will experience them. Side effects that are considered to be common include skin dryness, redness, irritation, or itching. Less commonly, skin pain or discomfort has been reported.

For a full list of potential side effects and other important information, please read the patient leaflet provided in the pack before starting any course of treatment. The leaflets can also be viewed online here: Differin Cream, Differin Gel.

Online consultations are available through our convenient and confidential Online Doctor service, which could lead to Differin Cream and Gel being prescribed for the treatment of acne, to start, click the button below.

Why choose Pharmacy2U

  • UK Registered GPs
  • Choose your preferred treatment
  • Regulated by the Care Quality Commission
Start Consultation

Online GP Consultations in 3 straightforward steps

Sign up to our newsletter Sign up to receive Pharmacy2U emails. We'll keep you up-to-date with our latest products & services, including exclusive discounts.