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What is Climaval?

Climaval tablets contain the active ingredient estradiol valerate, in a strength of either 1mg or 2mg per tablet.

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How does Climaval Tablets?

Estradiol valerate is a synthetic form of the oestrogen that is found naturally in the body. It is chemically and biologically identical to human oestradiol. Climaval tablets are a form of hormone replacement therapy (HRT), and are prescribed to women after the menopause to replace the oestrogen that’s no longer being produced. This helps to relieve the symptoms of the menopause, and restores the protective effect oestrogen has against the risk of cardiovascular disease.

How to take Climaval?

Please carefully read the enclosed leaflet before using Climaval tablets.

The dose is one tablet, which should be taken daily. This can be before or after food, but try to keep to the same time each day. Depending on the severity of your symptoms, the doctor might recommend the 1mg tablets or the 2mg tablets.

Climaval tablets are taken every day, unlike some oral contraceptives where there is a seven-day break.

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Is Climaval suitable for me?

Climaval tablets are only intended for women who have had a hysterectomy. For women who still have a uterus (womb), a form of HRT that also contains a progestogen should be used. This is to prevent overgrowth of tissue in the uterus and the complications that can develop because of that.

Just like all treatments, there are certain situations where Climaval tablets would not be recommended, or they should be used cautiously. For example, in women aged 65 and over, or those with cancer or a history of cancer; undiagnosed genital bleeding; liver or kidney problems and untreated endometrial hyperplasia (excessive growth of tissue in the womb). It may not be recommended if you currently have, or have been known to have in the past, venous thromboembolism (deep vein thrombosis, or pulmonary embolism); disorders of blood clotting and current or previous circulation problems, including angina or a heart attack. Porphyria and allergies to any of the active or inactive ingredients are also signs that Climaval isn’t suitable for you.

As well as the above, it is important to mention to the doctor if you have now, or have had in the past, any of these conditions: endometriosis, risk factors for thromboembolic disorders (that could be major surgery, prolonged immobilisation, obesity or cancer), risk factors for oestrogen dependent tumours, hypertension, and liver or kidney problems (for example, liver adenoma). You should also make the online doctor fully aware if you suffer from diabetes mellitus with or without vascular involvement, cholelithiasis, migraine or (severe) headaches or systemic lupus erythematosus (SLE). Plus, the doctor should also be told if you have a history of endometrial hyperplasia, epilepsy, asthma, or otosclerosis.

Whether they’re bought from a pharmacy or prescribed by a doctor, it's important you make the doctor aware of any other medicines you are taking. Climaval tablets can cause problems if taken with certain other medicines – this includes some medicines associated with epilepsy, and others that used to treat infections (for example rifampicin, rifabutin, nevirapine, efavirenz). Meanwhile, some medicines for HIV/AIDS won’t be compatible with Climaval, nor will warfarin and other anticoagulants, and St John's Wort (which is a herbal preparation). You should be sure to provide the doctor with as many details as possible about your general health in the consultation, to make sure they have all the information required to assess whether Climaval is the right treatment and should be recommended for you.

What are the side effects of Climaval?

Although not everybody gets them, you may experience side effects while taking Climaval.

Some side effects are potentially serious. If you experience any of the following, you should stop taking Climaval and consult with your local doctor immediately.

  • Unexpected vaginal bleeding or spotting (breakthrough bleeding) after taking Climaval for some time, or after you stop treatment
  • Painful periods
  • Swelling and redness of the legs that becomes painful
  • Chest pain that comes on suddenly
  • Difficulty in breathing
  • Pain in your chest that spreads to your arm or neck
  • Yellowing of the eyes and face (also known as jaundice)
  • Rapid increase in blood pressure
  • Migraine-like headaches for which the cause cannot be determined
  • Breast changes (this may include dimpling of the breast skin, any noticeable changes in the nipple or  lumps that weren’t there before).

Other reported side effects have included breast pain, vaginal discharge, headache, dizziness, increased libido, depression, increased blood pressure, and palpitations. You may also want to look out for fluid retention, nose bleeds, indigestion (and any other type of stomach discomfort), as well as itching, skin rashes, hair loss, weight gain, sweating, and the feeling that you may faint after eating.

The risk of thrombosis, stroke, endometrial cancer, breast cancer, and ovarian cancer are increased when undergoing HRT. As well as this, there is also an increased risk of heart disease in women who begin a course of HRT 10 years or more following the start of the menopause. That’s why care is taken to prescribe the minimum effective dose of HRT, and it should only used for the shortest length of time.

You'll find a full list of potential side effects and other important information in the patient information leaflet, which is provided within the pack – you should read this before starting any course of treatment. The leaflet can also be viewed online here.

Online consultations are available through the Pharmacy2U Online Doctor service, which could lead to prescription-strength HRT treatments being arranged for you.

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